Cargando…

The beneficial effects of a muscarinic agonist on pancreatic β-cells

The brain and nervous system play an important role in pancreatic β-cell function. This study investigated the role of muscarinic agonists or acetylcholine, which is the major neurotransmitter in the vagal nerve, in regulating pancreatic β-cell mass and glucose homeostasis. Administration of the mus...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ito, Yuzuru, Kaji, Mitsuyo, Sakamoto, Eri, Terauchi, Yasuo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838462/ https://www.ncbi.nlm.nih.gov/pubmed/31700039 http://dx.doi.org/10.1038/s41598-019-52691-8

Ejemplares similares

Glucokinase Activation Ameliorates ER Stress–Induced Apoptosis in Pancreatic β-Cells
por: Shirakawa, Jun, et al.
Publicado: (2013)

AMPK Is Involved in the Regulation of Incretin Receptors Expression in Pancreatic Islets under a Low Glucose Concentration
por: Tajima, Kazuki, et al.
Publicado: (2013)

Diet-Induced Adipose Tissue Inflammation and Liver Steatosis Are Prevented by DPP-4 Inhibition in Diabetic Mice
por: Shirakawa, Jun, et al.
Publicado: (2011)

Muscarinic Receptor Agonists and Antagonists
por: Broadley, Kenneth J., et al.
Publicado: (2001)

Synchronization of pancreatic islets by periodic or non-periodic muscarinic agonist pulse trains
por: Adablah, Joel E., et al.
Publicado: (2019)

DREADD Agonist 21 Is an Effective Agonist for Muscarinic-Based DREADDs in Vitro and in Vivo
por: Thompson, Karen J., et al.
Publicado: (2018)

G protein‐coupled receptor 119 agonist DS‐8500a effects on pancreatic β‐cells in Japanese type 2 diabetes mellitus patients
por: Watada, Hirotaka, et al.
Publicado: (2018)

Muscarinic receptor agonist-induced βPix binding to β-catenin promotes colon neoplasia
por: Cheng, Kunrong, et al.
Publicado: (2023)

Multitargeting nature of muscarinic orthosteric agonists and antagonists
por: Myslivecek, Jaromir
Publicado: (2022)

Effects of switching from liraglutide to semaglutide or dulaglutide in patients with type 2 diabetes: A randomized controlled trial
por: Iijima, Takahiro, et al.
Publicado: (2023)

Negative cooperativity in binding of muscarinic receptor agonists and GDP as a measure of agonist efficacy
por: Jakubík, J, et al.
Publicado: (2011)

Control of Brain State Transitions with a Photoswitchable Muscarinic Agonist
por: Barbero‐Castillo, Almudena, et al.
Publicado: (2021)

DPP-4 inhibition improves early mortality, β cell function, and adipose tissue inflammation in db/db mice fed a diet containing sucrose and linoleic acid
por: Shirakawa, Jun, et al.
Publicado: (2016)

The Role of Muscarinic Receptors in the Beneficial Effects of Adenosine against Myocardial Reperfusion Injury in Rats
por: Sun, Lei, et al.
Publicado: (2011)

Agonist-induced changes in the modulation of K+ permeability and beating rate by muscarinic agonists in cultured heart cells
Publicado: (1982)

The pharmacological rationale for combining muscarinic receptor antagonists and β-adrenoceptor agonists in the treatment of airway and bladder disease()
por: Dale, Philippa R, et al.
Publicado: (2014)

The NALCN ion channel is activated by M3 muscarinic receptors in a pancreatic β-cell line
por: Swayne, Leigh Anne, et al.
Publicado: (2009)

The muscarinic agonist arecoline suppresses motor circuit hyperactivity in C. elegans
por: McCulloch, Katherine A, et al.
Publicado: (2020)

The Bronchoprotective Effects of Dual Pharmacology, Muscarinic Receptor Antagonist and β(2) Adrenergic Receptor Agonist Navafenterol in Human Small Airways
por: Jude, Joseph Antony, et al.
Publicado: (2023)

Involvement of Ca(2+) Signaling in the Synergistic Effects between Muscarinic Receptor Antagonists and β(2)-Adrenoceptor Agonists in Airway Smooth Muscle
por: Fukunaga, Kentaro, et al.
Publicado: (2016)

Effects of a single long-acting muscarinic antagonist agent and a long-acting muscarinic antagonist/long-acting β2-adrenoceptor agonist combination on lung function and symptoms in untreated COPD patients in Japan
por: Yamada, Hideyasu, et al.
Publicado: (2018)

Optimal Bronchodilation for COPD Patients: Are All Long-Acting β(2)-Agonist/Long-Acting Muscarinic Antagonists the Same?
por: Miravitlles, Marc, et al.
Publicado: (2018)

Antipsychotic-Like Effect of the Muscarinic Acetylcholine Receptor Agonist BuTAC in Non-Human Primates
por: Andersen, Maibritt B., et al.
Publicado: (2015)

The Combination of the M2 Muscarinic Receptor Agonist and Chemotherapy Affects Drug Resistance in Neuroblastoma Cells
por: Lucianò, Anna Maria, et al.
Publicado: (2020)

Potential linkage between dipeptidyl peptidase‐4 inhibitor use and the risk of pancreatitis/pancreatic cancer
por: Shirakawa, Jun, et al.
Publicado: (2020)

Early to late sparing of radiation damage to the parotid gland by adrenergic and muscarinic receptor agonists
por: Coppes, R P, et al.
Publicado: (2001)

Long-acting muscarinic antagonists vs. long-acting β (2) agonists in COPD exacerbations: a systematic review and meta-analysis
por: Maia, Israel Silva, et al.
Publicado: (2017)

A Network Meta-Analysis of Long-Acting Muscarinic Antagonist (LAMA) and Long-Acting β(2)-Agonist (LABA) Combinations in COPD
por: Sion, Katya Y. J., et al.
Publicado: (2017)

Preparation of a First (18)F-Labeled Agonist for M(1) Muscarinic Acetylcholine Receptors
por: Zlatopolskiy, Boris D., et al.
Publicado: (2020)

Approved LXR agonists exert unspecific effects on pancreatic β-cell function
por: Maczewsky, Jonas, et al.
Publicado: (2020)

FRET-Based Detection of M(1) Muscarinic Acetylcholine Receptor Activation by Orthosteric and Allosteric Agonists
por: Markovic, Danijela, et al.
Publicado: (2012)

[(11)C]AF150(S), an agonist PET ligand for M1 muscarinic acetylcholine receptors
por: Buiter, Hans JC, et al.
Publicado: (2013)

Distinct Agonist Regulation of Muscarinic Acetylcholine M(2)-M(3) Heteromers and Their Corresponding Homomers
por: Aslanoglou, Despoina, et al.
Publicado: (2015)

Effects of (a Combination of) the Beta(2)-Adrenoceptor Agonist Indacaterol and the Muscarinic Receptor Antagonist Glycopyrrolate on Intrapulmonary Airway Constriction
por: Maarsingh, Harm, et al.
Publicado: (2021)

Metabolic recovery of lipodystrophy, liver steatosis, and pancreatic β cell proliferation after the withdrawal of OSI-906
por: Tajima, Kazuki, et al.
Publicado: (2017)

Selective and sequential loss of transcriptional factors: A hallmark of β‐cell failure in type 2 diabetes?
por: Shirakawa, Jun, et al.
Publicado: (2014)

Investigating the Unbinding of Muscarinic Antagonists from the Muscarinic 3 Receptor
por: Buigues, Pedro J., et al.
Publicado: (2023)

Differential Actions of Muscarinic Receptor Subtypes in Gastric, Pancreatic, and Colon Cancer
por: Schledwitz, Alyssa, et al.
Publicado: (2021)

Glucose‐ or insulin resistance‐mediated β‐cell replication: PKCζ integrates the proliferative signaling
por: Shirakawa, Jun, et al.
Publicado: (2016)

Effects of extracellular ATP on ion transport systems and [Ca2+]i in rat parotid acinar cells. Comparison with the muscarinic agonist carbachol
Publicado: (1990)

Cannot write session to /tmp/vufind_sessions/sess_16vpmfmbmmfr2pnq9r0g931at0