Application of a genome-scale model in tandem with enzyme assays for identification of metabolic signatures of high and low CHO cell producers

Biopharmaceutical industrial processes are based on high yielding stable recombinant Chinese Hamster Ovary (CHO) cells that express monoclonal antibodies. However, the process and feeding regimes need to be adapted for each new cell line, as they all have a slightly different metabolism and product...

Descripción completa

Detalles Bibliográficos
Autores principales: Calmels, Cyrielle, Arnoult, Solène, Ben Yahia, Bassem, Malphettes, Laetitia, Andersen, Mikael Rørdam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838488/
https://www.ncbi.nlm.nih.gov/pubmed/31720213
http://dx.doi.org/10.1016/j.mec.2019.e00097

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838488/
https://www.ncbi.nlm.nih.gov/pubmed/31720213
http://dx.doi.org/10.1016/j.mec.2019.e00097

Ejemplares similares