A healthy patient with positive mantoux test but negative quantiferon Gold assay and no evidence of risk factors – to treat or not to treat?

A 56-year-old woman who vaccinated as a child with the Bacillus Calmette-Guerin (BCG), now tests positive to the tuberculin skin test (TST) but test negative to the Quantiferon Gold assay. She has no history of tuberculosis contact and is asymptomatic. This dilemma now is, should be treated for tube...

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Autores principales: Montane Jaime, Lazara Karelia, Akpaka, Patrick E., Vuma, Sehlule, Justiz-Vaillant, Angel A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838525/
https://www.ncbi.nlm.nih.gov/pubmed/31720225
http://dx.doi.org/10.1016/j.idcr.2019.e00658
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author Montane Jaime, Lazara Karelia
Akpaka, Patrick E.
Vuma, Sehlule
Justiz-Vaillant, Angel A
author_facet Montane Jaime, Lazara Karelia
Akpaka, Patrick E.
Vuma, Sehlule
Justiz-Vaillant, Angel A
author_sort Montane Jaime, Lazara Karelia
collection PubMed
description A 56-year-old woman who vaccinated as a child with the Bacillus Calmette-Guerin (BCG), now tests positive to the tuberculin skin test (TST) but test negative to the Quantiferon Gold assay. She has no history of tuberculosis contact and is asymptomatic. This dilemma now is, should be treated for tuberculosis or not, based only on the TST results? To prevent these falsepositive results with TST and avoid treatment with isoniazid (INH) it may be helpful to use interferon-gamma release assay (IGRA) instead, which unlike the TB skin test is not affected by prior BCG vaccination.
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spelling pubmed-68385252019-11-12 A healthy patient with positive mantoux test but negative quantiferon Gold assay and no evidence of risk factors – to treat or not to treat? Montane Jaime, Lazara Karelia Akpaka, Patrick E. Vuma, Sehlule Justiz-Vaillant, Angel A IDCases Article A 56-year-old woman who vaccinated as a child with the Bacillus Calmette-Guerin (BCG), now tests positive to the tuberculin skin test (TST) but test negative to the Quantiferon Gold assay. She has no history of tuberculosis contact and is asymptomatic. This dilemma now is, should be treated for tuberculosis or not, based only on the TST results? To prevent these falsepositive results with TST and avoid treatment with isoniazid (INH) it may be helpful to use interferon-gamma release assay (IGRA) instead, which unlike the TB skin test is not affected by prior BCG vaccination. Elsevier 2019-10-15 /pmc/articles/PMC6838525/ /pubmed/31720225 http://dx.doi.org/10.1016/j.idcr.2019.e00658 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Montane Jaime, Lazara Karelia
Akpaka, Patrick E.
Vuma, Sehlule
Justiz-Vaillant, Angel A
A healthy patient with positive mantoux test but negative quantiferon Gold assay and no evidence of risk factors – to treat or not to treat?
title A healthy patient with positive mantoux test but negative quantiferon Gold assay and no evidence of risk factors – to treat or not to treat?
title_full A healthy patient with positive mantoux test but negative quantiferon Gold assay and no evidence of risk factors – to treat or not to treat?
title_fullStr A healthy patient with positive mantoux test but negative quantiferon Gold assay and no evidence of risk factors – to treat or not to treat?
title_full_unstemmed A healthy patient with positive mantoux test but negative quantiferon Gold assay and no evidence of risk factors – to treat or not to treat?
title_short A healthy patient with positive mantoux test but negative quantiferon Gold assay and no evidence of risk factors – to treat or not to treat?
title_sort healthy patient with positive mantoux test but negative quantiferon gold assay and no evidence of risk factors – to treat or not to treat?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838525/
https://www.ncbi.nlm.nih.gov/pubmed/31720225
http://dx.doi.org/10.1016/j.idcr.2019.e00658
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