Cargando…

Reductions in COQ2 Expression Relate to Reduced ATP Levels in Multiple System Atrophy Brain

Multiple system atrophy (MSA) is a progressive neurodegenerative disease clinically characterized by parkinsonism and cerebellar ataxia, and pathologically by oligodendrocyte α-synuclein inclusions. Genetic variants of COQ2 are associated with an increased risk for MSA in certain populations. Also,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hsiao, Jen-Hsiang T., Purushothuman, Sivaraman, Jensen, Poul H., Halliday, Glenda M., Kim, Woojin Scott
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838639/ https://www.ncbi.nlm.nih.gov/pubmed/31736705 http://dx.doi.org/10.3389/fnins.2019.01187

Ejemplares similares

Cross-examining candidate genes implicated in multiple system atrophy
por: Katzeff, Jared S., et al.
Publicado: (2019)

Altered lipid levels provide evidence for myelin dysfunction in multiple system atrophy
por: Don, Anthony S, et al.
Publicado: (2014)

Role of Oligodendrocyte Lineage Cells in Multiple System Atrophy
por: Hsiao, Jen-Hsiang T., et al.
Publicado: (2023)

Animal modeling an oligodendrogliopathy – multiple system atrophy
por: Bleasel, Jonathan M., et al.
Publicado: (2016)

Exploring Myelin Dysfunction in Multiple System Atrophy
por: Wong, Joanna H., et al.
Publicado: (2014)

Lipid dysfunction and pathogenesis of multiple system atrophy
por: Bleasel, Jonathan M, et al.
Publicado: (2014)

Analysis of COQ2 gene in multiple system atrophy
por: Ogaki, Kotaro, et al.
Publicado: (2014)

α-Synuclein Regulates Neuronal Cholesterol Efflux
por: Hsiao, Jen-Hsiang T., et al.
Publicado: (2017)

ATP-binding cassette transporter expression is widely dysregulated in frontotemporal dementia with TDP-43 inclusions
por: Katzeff, Jared S., et al.
Publicado: (2022)

ATP-binding cassette transporters as possible targets for the intervention of neurodegenerative diseases
por: Lok, Hiu Chuen, et al.
Publicado: (2023)

Deletion of Alzheimer’s Disease Risk Gene ABCA7 Alters White Adipose Tissue Development and Leptin Levels
por: Bhatia, Surabhi, et al.
Publicado: (2017)

Elevation in Sphingomyelin Synthase Activity Is Associated with Increases in Amyloid-Beta Peptide Generation
por: Hsiao, Jen-Hsiang T., et al.
Publicado: (2013)

New susceptible variant of COQ2 gene in Japanese patients with sporadic multiple system atrophy
por: Sun, Zhuoran, et al.
Publicado: (2016)

COQ6 mutation in patients with nephrotic syndrome, sensorineural deafness, and optic atrophy
por: Justine Perrin, R., et al.
Publicado: (2020)

Composition of the Inner Nuclear Layer in Human Retina
por: Masri, Rania A., et al.
Publicado: (2021)

Tit-Coq /
por: Gélinas, Gratien
Publicado: (1981)

Extensive Delayed Brain Atrophy after Resuscitation in a Patient with Multiple System Atrophy
por: Nisitani, Sazuku, et al.
Publicado: (2018)

FAS-Dependent Cell Death in α-Synuclein Transgenic Oligodendrocyte Models of Multiple System Atrophy
por: Kragh, Christine L., et al.
Publicado: (2013)

Characterization of Arabidopsis thaliana Coq9 in the CoQ Biosynthetic Pathway
por: Hu, Mei, et al.
Publicado: (2023)

Lipidomics Analysis of Behavioral Variant Frontotemporal Dementia: A Scope for Biomarker Development
por: Kim, Woojin Scott, et al.
Publicado: (2018)

ATP13A2 (PARK9) protein levels are reduced in brain tissue of cases with Lewy bodies
por: Murphy, Karen E, et al.
Publicado: (2013)

β‐RA reduces DMQ/CoQ ratio and rescues the encephalopathic phenotype in Coq9 (R239X) mice
por: Hidalgo‐Gutiérrez, Agustín, et al.
Publicado: (2018)

Lethal Neonatal CoQ Deficiency due to a COQ9 Variant
por: Finsterer, Josef, et al.
Publicado: (2018)

Vanillic Acid Restores Coenzyme Q Biosynthesis and ATP Production in Human Cells Lacking COQ6
por: Acosta Lopez, Manuel J., et al.
Publicado: (2019)

Altered High Density Lipoprotein Composition in Behavioral Variant Frontotemporal Dementia
por: Kim, Woojin Scott, et al.
Publicado: (2018)

Reduction in Volume of Nucleus Basalis of Meynert Is Specific to Parkinson’s Disease and Progressive Supranuclear Palsy but Not to Multiple System Atrophy
por: Rogozinski, Sophia, et al.
Publicado: (2022)

Freezing of Gait in Multiple System Atrophy
por: Yang, Huaguang, et al.
Publicado: (2022)

Reduced Cytosolic Calcium as an Early Decisive Cellular State in Parkinson’s Disease and Synucleinopathies
por: Betzer, Cristine, et al.
Publicado: (2018)

Alpha-synuclein activates the classical complement pathway and mediates complement-dependent cell toxicity
por: Gregersen, Emil, et al.
Publicado: (2021)

Le coq de bruyére /
por: Tournier, Michel
Publicado: (1978)

CoQ10 and Aging
por: de Barcelos, Isabella Peixoto, et al.
Publicado: (2019)

Parkinson’s disease-implicated kinases in the brain; insights into disease pathogenesis
por: Dzamko, Nicolas, et al.
Publicado: (2014)

Metal-Dependent Regulation of ATP7A and ATP7B in Fibroblast Cultures
por: Lenartowicz, Malgorzata, et al.
Publicado: (2016)

4‐Hydroxybenzoic acid restores CoQ(10) biosynthesis in human COQ2 deficiency
por: Herebian, Diran, et al.
Publicado: (2017)

Coq Rouge : la historia de un espia sueco
por: Guillou, Jan
Publicado: (1990)

Three-Year Follow-Up of High-Dose Ubiquinol Supplementation in a Case of Familial Multiple System Atrophy with Compound Heterozygous COQ2 Mutations
por: Mitsui, Jun, et al.
Publicado: (2017)

Prolyl oligopeptidase inhibition reduces alpha‐synuclein aggregation in a cellular model of multiple system atrophy
por: Cui, Hengjing, et al.
Publicado: (2021)

CoQ(10) Deficient Endothelial Cell Culture Model for the Investigation of CoQ(10) Blood–Brain Barrier Transport
por: Wainwright, Luke, et al.
Publicado: (2020)

Live cell in situ lysosomal GCase activity correlates to alpha-synuclein levels in human differentiated neurons with LRRK2 and GBA1 mutations
por: Labrador-Garrido, Adahir, et al.
Publicado: (2023)

Human COQ9 Rescues a coq9 Yeast Mutant by Enhancing Coenzyme Q Biosynthesis from 4-Hydroxybenzoic Acid and Stabilizing the CoQ-Synthome
por: He, Cuiwen H., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_088n8sk2b6vt8ust8sdaj52bur