Antisense Oligonucleotide Inhibition of MicroRNA-494 Halts Atherosclerotic Plaque Progression and Promotes Plaque Stabilization

We have previously shown that third-generation antisense (3GA) inhibition of 14q32 microRNA (miRNA)-494 reduced early development of atherosclerosis. However, patients at risk of atherosclerotic complications generally present with advanced and unstable lesions. Here, we administered 3GAs against 14...

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Detalles Bibliográficos
Autores principales: van Ingen, Eva, Foks, Amanda C., Kröner, Mara J., Kuiper, Johan, Quax, Paul H.A., Bot, Ilze, Nossent, Anne Yaël
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838792/
https://www.ncbi.nlm.nih.gov/pubmed/31689618
http://dx.doi.org/10.1016/j.omtn.2019.09.021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838792/
https://www.ncbi.nlm.nih.gov/pubmed/31689618
http://dx.doi.org/10.1016/j.omtn.2019.09.021

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