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Sequential EGFR mutation and ALK rearrangement in adenocarcinoma lung, with rare metastasis to bilateral breast, ovary and endometrium
With the advent of targeted therapies there was a paradigm shift in the treatment of metastatic adenocarcinoma of lung. Immuno-histopathology and molecular subtyping in metastatic adenocarcinoma lung have enabled personalized treatment for each patient. Oncogenic driver mutations in non-small cell l...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838794/ https://www.ncbi.nlm.nih.gov/pubmed/31720204 http://dx.doi.org/10.1016/j.rmcr.2019.100954 |
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author | Anjali, V.R. Pandey, Rambha Srivastava, Astha Rajeshwari, Madhu Pandey, Durgatosh Sharma, M.C. |
author_facet | Anjali, V.R. Pandey, Rambha Srivastava, Astha Rajeshwari, Madhu Pandey, Durgatosh Sharma, M.C. |
author_sort | Anjali, V.R. |
collection | PubMed |
description | With the advent of targeted therapies there was a paradigm shift in the treatment of metastatic adenocarcinoma of lung. Immuno-histopathology and molecular subtyping in metastatic adenocarcinoma lung have enabled personalized treatment for each patient. Oncogenic driver mutations in non-small cell lung cancer are commonly EGFR (Epidermal Growth Factor Receptor) gene mutation and ALK (Anaplastic Lymphoma Kinase) gene rearrangement, which are mutually exclusive. Almost 60–64% patients have oncogenic mutation, which are mutually exclusive. Here, we present a case with EGFR mutation and ALK gene rearrangement which was expressed sequentially and with metastasis to rarest sites bilateral breast, ovaries and endometrium. Even though presented with upfront metastatic disease, patient was treated with multiple lines of targeted agents, by which patient survived for 5 years with good quality of life. |
format | Online Article Text |
id | pubmed-6838794 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-68387942019-11-12 Sequential EGFR mutation and ALK rearrangement in adenocarcinoma lung, with rare metastasis to bilateral breast, ovary and endometrium Anjali, V.R. Pandey, Rambha Srivastava, Astha Rajeshwari, Madhu Pandey, Durgatosh Sharma, M.C. Respir Med Case Rep Case Report With the advent of targeted therapies there was a paradigm shift in the treatment of metastatic adenocarcinoma of lung. Immuno-histopathology and molecular subtyping in metastatic adenocarcinoma lung have enabled personalized treatment for each patient. Oncogenic driver mutations in non-small cell lung cancer are commonly EGFR (Epidermal Growth Factor Receptor) gene mutation and ALK (Anaplastic Lymphoma Kinase) gene rearrangement, which are mutually exclusive. Almost 60–64% patients have oncogenic mutation, which are mutually exclusive. Here, we present a case with EGFR mutation and ALK gene rearrangement which was expressed sequentially and with metastasis to rarest sites bilateral breast, ovaries and endometrium. Even though presented with upfront metastatic disease, patient was treated with multiple lines of targeted agents, by which patient survived for 5 years with good quality of life. Elsevier 2019-10-19 /pmc/articles/PMC6838794/ /pubmed/31720204 http://dx.doi.org/10.1016/j.rmcr.2019.100954 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Anjali, V.R. Pandey, Rambha Srivastava, Astha Rajeshwari, Madhu Pandey, Durgatosh Sharma, M.C. Sequential EGFR mutation and ALK rearrangement in adenocarcinoma lung, with rare metastasis to bilateral breast, ovary and endometrium |
title | Sequential EGFR mutation and ALK rearrangement in adenocarcinoma lung, with rare metastasis to bilateral breast, ovary and endometrium |
title_full | Sequential EGFR mutation and ALK rearrangement in adenocarcinoma lung, with rare metastasis to bilateral breast, ovary and endometrium |
title_fullStr | Sequential EGFR mutation and ALK rearrangement in adenocarcinoma lung, with rare metastasis to bilateral breast, ovary and endometrium |
title_full_unstemmed | Sequential EGFR mutation and ALK rearrangement in adenocarcinoma lung, with rare metastasis to bilateral breast, ovary and endometrium |
title_short | Sequential EGFR mutation and ALK rearrangement in adenocarcinoma lung, with rare metastasis to bilateral breast, ovary and endometrium |
title_sort | sequential egfr mutation and alk rearrangement in adenocarcinoma lung, with rare metastasis to bilateral breast, ovary and endometrium |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838794/ https://www.ncbi.nlm.nih.gov/pubmed/31720204 http://dx.doi.org/10.1016/j.rmcr.2019.100954 |
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