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Diabetic kidney diseases revisited: A new perspective for a new era

BACKGROUND: Globally, diabetic kidney disease (DKD) is the leading cause of end-stage renal disease. As the most common microvascular complication of diabetes, DKD is a thorny, clinical problem in terms of its diagnosis and management. Intensive glucose control in DKD could slow down but not signifi...

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Autores principales: Fu, Haiyan, Liu, Silvia, Bastacky, Sheldon I., Wang, Xiaojie, Tian, Xiao-Jun, Zhou, Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838932/
https://www.ncbi.nlm.nih.gov/pubmed/31767176
http://dx.doi.org/10.1016/j.molmet.2019.10.005
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author Fu, Haiyan
Liu, Silvia
Bastacky, Sheldon I.
Wang, Xiaojie
Tian, Xiao-Jun
Zhou, Dong
author_facet Fu, Haiyan
Liu, Silvia
Bastacky, Sheldon I.
Wang, Xiaojie
Tian, Xiao-Jun
Zhou, Dong
author_sort Fu, Haiyan
collection PubMed
description BACKGROUND: Globally, diabetic kidney disease (DKD) is the leading cause of end-stage renal disease. As the most common microvascular complication of diabetes, DKD is a thorny, clinical problem in terms of its diagnosis and management. Intensive glucose control in DKD could slow down but not significantly halt disease progression. Revisiting the tremendous advances that have occurred in the field would enhance recognition of DKD pathogenesis as well as improve our understanding of translational science in DKD in this new era. SCOPE OF REVIEW: In this review, we summarize advances in the understanding of the local microenvironmental changes in diabetic kidneys and discuss the involvement of genetic and epigenetic factors in the pathogenesis of DKD. We also review DKD prevalence changes and analyze the challenges in optimizing the diagnostic approaches and management strategies for DKD in the clinic. As we enter the era of ‘big data’, we also explore the possibility of linking systems biology with translational medicine in DKD in the current healthcare system. MAJOR CONCLUSION: Newer understanding of the structural changes of diabetic kidneys and mechanisms of DKD pathogenesis, as well as emergent research technologies will shed light on new methods of dealing with the existing clinical challenges of DKD.
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spelling pubmed-68389322019-11-12 Diabetic kidney diseases revisited: A new perspective for a new era Fu, Haiyan Liu, Silvia Bastacky, Sheldon I. Wang, Xiaojie Tian, Xiao-Jun Zhou, Dong Mol Metab Review BACKGROUND: Globally, diabetic kidney disease (DKD) is the leading cause of end-stage renal disease. As the most common microvascular complication of diabetes, DKD is a thorny, clinical problem in terms of its diagnosis and management. Intensive glucose control in DKD could slow down but not significantly halt disease progression. Revisiting the tremendous advances that have occurred in the field would enhance recognition of DKD pathogenesis as well as improve our understanding of translational science in DKD in this new era. SCOPE OF REVIEW: In this review, we summarize advances in the understanding of the local microenvironmental changes in diabetic kidneys and discuss the involvement of genetic and epigenetic factors in the pathogenesis of DKD. We also review DKD prevalence changes and analyze the challenges in optimizing the diagnostic approaches and management strategies for DKD in the clinic. As we enter the era of ‘big data’, we also explore the possibility of linking systems biology with translational medicine in DKD in the current healthcare system. MAJOR CONCLUSION: Newer understanding of the structural changes of diabetic kidneys and mechanisms of DKD pathogenesis, as well as emergent research technologies will shed light on new methods of dealing with the existing clinical challenges of DKD. Elsevier 2019-10-17 /pmc/articles/PMC6838932/ /pubmed/31767176 http://dx.doi.org/10.1016/j.molmet.2019.10.005 Text en © 2019 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Fu, Haiyan
Liu, Silvia
Bastacky, Sheldon I.
Wang, Xiaojie
Tian, Xiao-Jun
Zhou, Dong
Diabetic kidney diseases revisited: A new perspective for a new era
title Diabetic kidney diseases revisited: A new perspective for a new era
title_full Diabetic kidney diseases revisited: A new perspective for a new era
title_fullStr Diabetic kidney diseases revisited: A new perspective for a new era
title_full_unstemmed Diabetic kidney diseases revisited: A new perspective for a new era
title_short Diabetic kidney diseases revisited: A new perspective for a new era
title_sort diabetic kidney diseases revisited: a new perspective for a new era
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838932/
https://www.ncbi.nlm.nih.gov/pubmed/31767176
http://dx.doi.org/10.1016/j.molmet.2019.10.005
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