Chicken MBD4 Regulates Immunoglobulin Diversification by Somatic Hypermutation

Immunoglobulin (Ig) diversification occurs via somatic hypermutation (SHM) and class switch recombination (CSR), and is initiated by activation-induced deaminase (AID), which converts cytosine to uracil. Variable (V) region genes undergo SHM to create amino acid substitutions that produce antibodies...

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Detalles Bibliográficos
Autores principales: Costello, Ryan, Cantillo, Jose F., Kenter, Amy L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838969/
https://www.ncbi.nlm.nih.gov/pubmed/31736964
http://dx.doi.org/10.3389/fimmu.2019.02540

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838969/
https://www.ncbi.nlm.nih.gov/pubmed/31736964
http://dx.doi.org/10.3389/fimmu.2019.02540

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