Cargando…

Chicken MBD4 Regulates Immunoglobulin Diversification by Somatic Hypermutation

Immunoglobulin (Ig) diversification occurs via somatic hypermutation (SHM) and class switch recombination (CSR), and is initiated by activation-induced deaminase (AID), which converts cytosine to uracil. Variable (V) region genes undergo SHM to create amino acid substitutions that produce antibodies...

Descripción completa

Detalles Bibliográficos
Autores principales:	Costello, Ryan, Cantillo, Jose F., Kenter, Amy L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838969/ https://www.ncbi.nlm.nih.gov/pubmed/31736964 http://dx.doi.org/10.3389/fimmu.2019.02540

Ejemplares similares

Tandem Substitutions in Somatic Hypermutation
por: Sepúlveda-Yáñez, Julieta H., et al.
Publicado: (2022)

A Diverse Repertoire of Human Immunoglobulin Variable Genes in a Chicken B Cell Line is Generated by Both Gene Conversion and Somatic Hypermutation
por: Leighton, Philip A., et al.
Publicado: (2015)

Complex Relationship between Mismatch Repair Proteins and MBD4 during Immunoglobulin Class Switch Recombination
por: Grigera, Fernando, et al.
Publicado: (2013)

Models of Somatic Hypermutation Targeting and Substitution Based on Synonymous Mutations from High-Throughput Immunoglobulin Sequencing Data
por: Yaari, Gur, et al.
Publicado: (2013)

Somatic hypermutation of an immunoglobulin mu heavy chain transgene
Publicado: (1993)

The Role of DNA Repair in Somatic Hypermutation of Immunoglobulin Genes
por: Kim, Nayun, et al.
Publicado: (1998)

Expression of Constitutive Fusion of Ubiquitin to PCNA Restores the Level of Immunoglobulin A/T Mutations During Somatic Hypermutation in the Ramos Cell Line
por: Lerner, Leticia K., et al.
Publicado: (2022)

Mutating for Good: DNA Damage Responses During Somatic Hypermutation
por: Pilzecker, Bas, et al.
Publicado: (2019)

Somatic Hypermutation Introduces Insertions and Deletions into Immunoglobulin V Genes
por: Wilson, Patrick C., et al.
Publicado: (1998)

Targeting Of Somatic Hypermutation By immunoglobulin Enhancer And Enhancer-Like Sequences
por: Buerstedde, Jean-Marie, et al.
Publicado: (2014)

Chronic Lymphocytic Leukemia B Cells Can Undergo Somatic Hypermutation and Intraclonal Immunoglobulin V(H)DJ(H) Gene Diversification
por: Gurrieri, Carmela, et al.
Publicado: (2002)

Structural Basis of Antibody Conformation and Stability Modulation by Framework Somatic Hypermutation
por: Sheng, Zizhang, et al.
Publicado: (2022)

Control of gene conversion and somatic hypermutation by immunoglobulin promoter and enhancer sequences
por: Yang, Shu Yuan, et al.
Publicado: (2006)

Intricate targeting of immunoglobulin somatic hypermutation maximizes the efficiency of affinity maturation
por: Zheng, Nai-Ying, et al.
Publicado: (2005)

Reverse Transcriptase Mechanism of Somatic Hypermutation: 60 Years of Clonal Selection Theory
por: Steele, Edward J.
Publicado: (2017)

Beyond Hot Spots: Biases in Antibody Somatic Hypermutation and Implications for Vaccine Design
por: Schramm, Chaim A., et al.
Publicado: (2018)

Altered somatic hypermutation patterns in COVID-19 patients classifies disease severity
por: Safra, Modi, et al.
Publicado: (2023)

Disparate roles of ATR and ATM in immunoglobulin class switch recombination and somatic hypermutation
por: Pan-Hammarström, Qiang, et al.
Publicado: (2006)

HMCES protects immunoglobulin genes specifically from deletions during somatic hypermutation
por: Wu, Lizhen, et al.
Publicado: (2022)

Somatic hypermutation of T cell receptor α chain contributes to selection in nurse shark thymus
por: Ott, Jeannine A, et al.
Publicado: (2018)

Altering the spectrum of immunoglobulin V gene somatic hypermutation by modifying the active site of AID
por: Wang, Meng, et al.
Publicado: (2010)

Outlier response to anti-PD1 in uveal melanoma reveals germline MBD4 mutations in hypermutated tumors
por: Rodrigues, Manuel, et al.
Publicado: (2018)

T Cell Receptor Alpha Chain Genes in the Teleost Ballan Wrasse (Labrus bergylta) Are Subjected to Somatic Hypermutation
por: Bilal, Sumaira, et al.
Publicado: (2018)

Repertoire Sequencing of B Cells Elucidates the Role of UNG and Mismatch Repair Proteins in Somatic Hypermutation in Humans
por: IJspeert, Hanna, et al.
Publicado: (2019)

Checkpoint kinase 1 negatively regulates somatic hypermutation
por: Frankenberger, Samantha, et al.
Publicado: (2014)

Huwe1 supports B-cell development, B-cell-dependent immunity, somatic hypermutation and class switch recombination by regulating proliferation
por: Spanjaard, Aldo, et al.
Publicado: (2023)

Recurrent targets of aberrant somatic hypermutation in lymphoma
por: Khodabakhshi, Alireza Hadj, et al.
Publicado: (2012)

Continuing rearrangement but absence of somatic hypermutation in immunoglobulin genes of human B cell precursor leukemia
Publicado: (1988)

Bcl6 Is Required for Somatic Hypermutation and Gene Conversion in Chicken DT40 Cells
por: Williams, Alan M., et al.
Publicado: (2016)

Gene-Specific Substitution Profiles Describe the Types and Frequencies of Amino Acid Changes during Antibody Somatic Hypermutation
por: Sheng, Zizhang, et al.
Publicado: (2017)

The IgH Eµ-MAR regions promote UNG-dependent error-prone repair to optimize somatic hypermutation
por: Martin, Ophélie A., et al.
Publicado: (2023)

Attracting AID to targets of somatic hypermutation
por: Tanaka, Atsushi, et al.
Publicado: (2010)

Immunoglobulin somatic hypermutation in a defined biochemical system recapitulates affinity maturation and permits antibody optimization
por: Jeong, Soo Lim, et al.
Publicado: (2022)

AID function in somatic hypermutation and class switch recombination: AID function in somatic hypermutation and class switch recombination
por: Yu, Kefei
Publicado: (2022)

Identifying protein–protein interactions in somatic hypermutation
por: Goodman, Myron F., et al.
Publicado: (2005)

Correlations in Somatic Hypermutation Between Sites in IGHV Genes Can Be Explained by Interactions Between AID and/or Polη Hotspots
por: Krantsevich, Artem, et al.
Publicado: (2021)

Individual Sea Urchin Coelomocytes Undergo Somatic Immune Gene Diversification
por: Oren, Matan, et al.
Publicado: (2019)

Activation-induced Deaminase (AID)-directed Hypermutation in the Immunoglobulin Sμ Region: Implication of AID Involvement in a Common Step of Class Switch Recombination and Somatic Hypermutation
por: Nagaoka, Hitoshi, et al.
Publicado: (2002)

Combined Influence of B-Cell Receptor Rearrangement and Somatic Hypermutation on B-Cell Class-Switch Fate in Health and in Chronic Lymphocytic Leukemia
por: Petrova, Velislava N., et al.
Publicado: (2018)

P20-20 LB. Indels in V4 share sequence features with insertions and deletions during somatic hypermutation of immunoglobulins
por: Guglietta, S, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_cn1dtq0rrfui5el7ujasls2fbh