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Association of the maternal microbiome in Japanese pregnant women with the cumulative prevalence of dermatitis in early infancy: A pilot study from the Chiba study of Mother and Child Health birth cohort

BACKGROUND: The prenatal maternal microbiome, including the gut microbiota, has been suggested to influence the incidence of allergies in offspring. Moreover, epidermal barrier dysfunction in early infancy has been attributed to the development of subsequent allergies. We hypothesized that the prena...

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Autores principales: Tanabe, Hiromi, Sakurai, Kenichi, Kato, Tamotsu, Kawasaki, Yohei, Nakano, Taiji, Yamaide, Fumiya, Taguchi-Atarashi, Naoko, Watanabe, Masahiro, Ochiai, Shingo, Ohno, Hiroshi, Fukuoka, Hideoki, Shimojo, Naoki, Mori, Chisato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: World Allergy Organization 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838981/
https://www.ncbi.nlm.nih.gov/pubmed/31719945
http://dx.doi.org/10.1016/j.waojou.2019.100065
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author Tanabe, Hiromi
Sakurai, Kenichi
Kato, Tamotsu
Kawasaki, Yohei
Nakano, Taiji
Yamaide, Fumiya
Taguchi-Atarashi, Naoko
Watanabe, Masahiro
Ochiai, Shingo
Ohno, Hiroshi
Fukuoka, Hideoki
Shimojo, Naoki
Mori, Chisato
author_facet Tanabe, Hiromi
Sakurai, Kenichi
Kato, Tamotsu
Kawasaki, Yohei
Nakano, Taiji
Yamaide, Fumiya
Taguchi-Atarashi, Naoko
Watanabe, Masahiro
Ochiai, Shingo
Ohno, Hiroshi
Fukuoka, Hideoki
Shimojo, Naoki
Mori, Chisato
author_sort Tanabe, Hiromi
collection PubMed
description BACKGROUND: The prenatal maternal microbiome, including the gut microbiota, has been suggested to influence the incidence of allergies in offspring. Moreover, epidermal barrier dysfunction in early infancy has been attributed to the development of subsequent allergies. We hypothesized that the prenatal microbiome may affect the gut microbiota, acting as an initial trigger to alter immune development in the foetus. The maternal microbial composition may be linked to the prevalence of dermatitis in early infancy (DEI) of the offspring, leading to subsequent allergic symptoms. METHODS: This study was conducted as part of the Chiba Study of Mother and Child Health (C-MACH) birth cohort that was initiated in 2013; 434 healthy pregnant women at < 13 weeks of gestation were recruited. DEI was assessed for up to 4 months after birth, and allergic symptoms were determined in 10-month-old infants using questionnaires. Other information related to the maternal microbiome was obtained from questionnaires filled out during pregnancy. Stool samples were collected from pregnant women at 12 (n = 59) and 32 weeks (n = 58) of gestation, which were used for gut microbiota analysis using barcoded 16S rRNA gene sequencing. RESULTS: Symptoms of allergy, especially of inherited allergies, show a higher prevalence at 10 months after birth in the DEI group. DEI occurrence was negatively correlated with family size and cat ownership. The diversity of Proteobacteria at 12 weeks of gestation and the relative abundance of Actinobacteria at 32 weeks of gestation in maternal feces were lower at both time points of gestation in the DEI group. In addition, the diversity of Proteobacteria in prenatal feces was negatively correlated with family size at 12 weeks, and with dog ownership at both gestational time points. CONCLUSIONS: The composition of the maternal microbiome may influence the risk of allergies in offspring, even before birth. Furthermore, the diversity of Proteobacteria and the relative abundance of Actinobacteria in maternal feces were negatively associated with DEI, which may be associated with the risk of allergy development in infancy. This early trigger may be a good predictor of allergy development during infancy and childhood.
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spelling pubmed-68389812019-11-12 Association of the maternal microbiome in Japanese pregnant women with the cumulative prevalence of dermatitis in early infancy: A pilot study from the Chiba study of Mother and Child Health birth cohort Tanabe, Hiromi Sakurai, Kenichi Kato, Tamotsu Kawasaki, Yohei Nakano, Taiji Yamaide, Fumiya Taguchi-Atarashi, Naoko Watanabe, Masahiro Ochiai, Shingo Ohno, Hiroshi Fukuoka, Hideoki Shimojo, Naoki Mori, Chisato World Allergy Organ J Article BACKGROUND: The prenatal maternal microbiome, including the gut microbiota, has been suggested to influence the incidence of allergies in offspring. Moreover, epidermal barrier dysfunction in early infancy has been attributed to the development of subsequent allergies. We hypothesized that the prenatal microbiome may affect the gut microbiota, acting as an initial trigger to alter immune development in the foetus. The maternal microbial composition may be linked to the prevalence of dermatitis in early infancy (DEI) of the offspring, leading to subsequent allergic symptoms. METHODS: This study was conducted as part of the Chiba Study of Mother and Child Health (C-MACH) birth cohort that was initiated in 2013; 434 healthy pregnant women at < 13 weeks of gestation were recruited. DEI was assessed for up to 4 months after birth, and allergic symptoms were determined in 10-month-old infants using questionnaires. Other information related to the maternal microbiome was obtained from questionnaires filled out during pregnancy. Stool samples were collected from pregnant women at 12 (n = 59) and 32 weeks (n = 58) of gestation, which were used for gut microbiota analysis using barcoded 16S rRNA gene sequencing. RESULTS: Symptoms of allergy, especially of inherited allergies, show a higher prevalence at 10 months after birth in the DEI group. DEI occurrence was negatively correlated with family size and cat ownership. The diversity of Proteobacteria at 12 weeks of gestation and the relative abundance of Actinobacteria at 32 weeks of gestation in maternal feces were lower at both time points of gestation in the DEI group. In addition, the diversity of Proteobacteria in prenatal feces was negatively correlated with family size at 12 weeks, and with dog ownership at both gestational time points. CONCLUSIONS: The composition of the maternal microbiome may influence the risk of allergies in offspring, even before birth. Furthermore, the diversity of Proteobacteria and the relative abundance of Actinobacteria in maternal feces were negatively associated with DEI, which may be associated with the risk of allergy development in infancy. This early trigger may be a good predictor of allergy development during infancy and childhood. World Allergy Organization 2019-11-01 /pmc/articles/PMC6838981/ /pubmed/31719945 http://dx.doi.org/10.1016/j.waojou.2019.100065 Text en © 2019 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tanabe, Hiromi
Sakurai, Kenichi
Kato, Tamotsu
Kawasaki, Yohei
Nakano, Taiji
Yamaide, Fumiya
Taguchi-Atarashi, Naoko
Watanabe, Masahiro
Ochiai, Shingo
Ohno, Hiroshi
Fukuoka, Hideoki
Shimojo, Naoki
Mori, Chisato
Association of the maternal microbiome in Japanese pregnant women with the cumulative prevalence of dermatitis in early infancy: A pilot study from the Chiba study of Mother and Child Health birth cohort
title Association of the maternal microbiome in Japanese pregnant women with the cumulative prevalence of dermatitis in early infancy: A pilot study from the Chiba study of Mother and Child Health birth cohort
title_full Association of the maternal microbiome in Japanese pregnant women with the cumulative prevalence of dermatitis in early infancy: A pilot study from the Chiba study of Mother and Child Health birth cohort
title_fullStr Association of the maternal microbiome in Japanese pregnant women with the cumulative prevalence of dermatitis in early infancy: A pilot study from the Chiba study of Mother and Child Health birth cohort
title_full_unstemmed Association of the maternal microbiome in Japanese pregnant women with the cumulative prevalence of dermatitis in early infancy: A pilot study from the Chiba study of Mother and Child Health birth cohort
title_short Association of the maternal microbiome in Japanese pregnant women with the cumulative prevalence of dermatitis in early infancy: A pilot study from the Chiba study of Mother and Child Health birth cohort
title_sort association of the maternal microbiome in japanese pregnant women with the cumulative prevalence of dermatitis in early infancy: a pilot study from the chiba study of mother and child health birth cohort
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838981/
https://www.ncbi.nlm.nih.gov/pubmed/31719945
http://dx.doi.org/10.1016/j.waojou.2019.100065
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