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Engineering of a Lectibody Targeting High-Mannose-Type Glycans of the HIV Envelope

High-mannose-type glycans (HMGs) are aberrantly enriched on HIV envelope glycoproteins. However, there is currently no drug selectively targeting HIV-associated HMGs. Here, we describe a novel HMG-targeting “lectibody,” a recombinant Fc-fusion protein comprising human IgG1 Fc and a novel actinohivin...

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Detalles Bibliográficos
Autores principales:	Hamorsky, Krystal Teasley, Kouokam, J. Calvin, Dent, Matthew W., Grooms, Tiffany N., Husk, Adam S., Hume, Steven D., Rogers, Kenneth A., Villinger, Francois, Morris, Mary Kate, Hanson, Carl V., Matoba, Nobuyuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2019
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839005/ https://www.ncbi.nlm.nih.gov/pubmed/31471224 http://dx.doi.org/10.1016/j.ymthe.2019.07.021

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