Domatinostat favors the immunotherapy response by modulating the tumor immune microenvironment (TIME)

BACKGROUND: The efficacy of PD-(L)1 blockade depends on the composition of the tumor immune microenvironment (TIME) and is generally higher in tumors with pre-existing cytotoxic T cells (CTL) than in those with low CTL numbers. Nonetheless, a significant proportion of patients with pre-existing immu...

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Detalles Bibliográficos
Autores principales: Bretz, Anne Catherine, Parnitzke, Ulrike, Kronthaler, Kerstin, Dreker, Tobias, Bartz, René, Hermann, Frank, Ammendola, Astrid, Wulff, Tanja, Hamm, Svetlana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839078/
https://www.ncbi.nlm.nih.gov/pubmed/31703604
http://dx.doi.org/10.1186/s40425-019-0745-3

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