Higher matrix stiffness as an independent initiator triggers epithelial-mesenchymal transition and facilitates HCC metastasis

BACKGROUND: Increased liver stiffness exerts a detrimental role in driving hepatocellular carcinoma (HCC) malignancy and progression, and indicates a high risk of unfavorable outcomes. However, it remains largely unknown how liver matrix stiffness as an independent cue triggers epithelial-mesenchyma...

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Detalles Bibliográficos
Autores principales: Dong, Yinying, Zheng, Qiongdan, Wang, Zhiming, Lin, Xiahui, You, Yang, Wu, Sifan, Wang, Yaohui, Hu, Chao, Xie, Xiaoying, Chen, Jie, Gao, Dongmei, Zhao, Yan, Wu, Weizhong, Liu, Yinkun, Ren, Zhenggang, Chen, Rongxin, Cui, Jiefeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839087/
https://www.ncbi.nlm.nih.gov/pubmed/31703598
http://dx.doi.org/10.1186/s13045-019-0795-5

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