Multiple Neurologic Deficits and Cognitive Decline in a Young Woman

We present the clinicopathologic conference of a 34-year-old lady with history of facial palsy 14 years ago who developed new deficits of mononeuritis multiplex, maculopapular rash, pancytopenia, splenomegaly, lung involvement and cognitive decline rapidly over three years. Investigations revealed p...

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Detalles Bibliográficos
Autores principales: Elavarasi, Arunmozhimaran, George, Jacob, Sharma, Mehar Chand, Kumari, Kalpana, Garg, Ajay, Pandit, Awadh Kishor, Satapathy, Abhishek, Goyal, Vinay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Clinicopathological Conference
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839316/
https://www.ncbi.nlm.nih.gov/pubmed/31736585
http://dx.doi.org/10.4103/aian.AIAN_293_19
Descripción
Sumario:We present the clinicopathologic conference of a 34-year-old lady with history of facial palsy 14 years ago who developed new deficits of mononeuritis multiplex, maculopapular rash, pancytopenia, splenomegaly, lung involvement and cognitive decline rapidly over three years. Investigations revealed pancytopenia, reversal of albumin globulin ratio, mediastinal adenopathy, ANA positivity, low C3 levels with the CSF being inflammatory and MRI showing extensive hemorrhagic lesions with mass effect. She had a rapidly progressive fatal course over three years with the disease being undiagnosed. This case was presented in the annual meeting of the Indian Academy of Neurology in September 2018.

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