Cargando…

Long-Term Effects of Traumatic Brain Injury in a Mouse Model of Alzheimer’s Disease

Alzheimer’s disease (AD) is the leading cause of dementia worldwide, affecting over 10% of the elderly population. Epidemiological evidence indicates that traumatic brain injury (TBI) is an important risk factor for developing AD later in life. However, which injury-induced processes that contribute...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zyśk, Marlena, Clausen, Fredrik, Aguilar, Ximena, Sehlin, Dag, Syvänen, Stina, Erlandsson, Anna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	IOS Press 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839469/ https://www.ncbi.nlm.nih.gov/pubmed/31561367 http://dx.doi.org/10.3233/JAD-190572

Ejemplares similares

Pinpointing Brain TREM2 Levels in Two Mouse Models of Alzheimer’s Disease
por: Meier, Silvio R., et al.
Publicado: (2021)

SPECT imaging of distribution and retention of a brain-penetrating bispecific amyloid-β antibody in a mouse model of Alzheimer’s disease
por: Gustavsson, Tobias, et al.
Publicado: (2020)

Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size
por: Faresjö, Rebecca, et al.
Publicado: (2021)

Engineered antibodies: new possibilities for brain PET?
por: Sehlin, Dag, et al.
Publicado: (2019)

Antibody-based PET imaging of amyloid beta in mouse models of Alzheimer's disease
por: Sehlin, Dag, et al.
Publicado: (2016)

Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer’s disease
por: Gustavsson, Tobias, et al.
Publicado: (2023)

Traumatic brain injury in the presence of Aβ pathology affects neuronal survival, glial activation and autophagy
por: Streubel-Gallasch, Linn, et al.
Publicado: (2021)

Age, dose, and binding to TfR on blood cells influence brain delivery of a TfR-transported antibody
por: Faresjö, Rebecca, et al.
Publicado: (2023)

Blood–brain barrier penetrating neprilysin degrades monomeric amyloid-beta in a mouse model of Alzheimer’s disease
por: Rofo, Fadi, et al.
Publicado: (2022)

Brain pharmacokinetics of mono- and bispecific amyloid-β antibodies in wild-type and Alzheimer’s disease mice measured by high cut-off microdialysis
por: Julku, Ulrika, et al.
Publicado: (2022)

The Aβ protofibril selective antibody mAb158 prevents accumulation of Aβ in astrocytes and rescues neurons from Aβ-induced cell death
por: Söllvander, Sofia, et al.
Publicado: (2018)

Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor
por: Hultqvist, Greta, et al.
Publicado: (2017)

ImmunoPET imaging of amyloid-beta in a rat model of Alzheimer’s disease with a bispecific, brain-penetrating fusion protein
por: Bonvicini, Gillian, et al.
Publicado: (2022)

Pharmacokinetics, biodistribution and brain retention of a bispecific antibody-based PET radioligand for imaging of amyloid-β
por: Sehlin, Dag, et al.
Publicado: (2017)

Enhanced neprilysin-mediated degradation of hippocampal Aβ42 with a somatostatin peptide that enters the brain
por: Rofo, Fadi, et al.
Publicado: (2021)

Transferrin Receptor Binding BBB-Shuttle Facilitates Brain Delivery of Anti-Aβ-Affibodies
por: Faresjö, Rebecca, et al.
Publicado: (2022)

A Brain-Targeting Bispecific-Multivalent Antibody Clears Soluble Amyloid-Beta Aggregates in Alzheimer’s Disease Mice
por: Rofo, Fadi, et al.
Publicado: (2022)

Reduction of αSYN Pathology in a Mouse Model of PD Using a Brain-Penetrating Bispecific Antibody
por: Roshanbin, Sahar, et al.
Publicado: (2022)

Fluorine-18-Labeled Antibody Ligands for PET Imaging of Amyloid-β in Brain
por: Syvänen, Stina, et al.
Publicado: (2020)

Efficient and inexpensive transient expression of multispecific multivalent antibodies in Expi293 cells
por: Fang, Xiaotian T., et al.
Publicado: (2017)

Neutrophil depletion reduces edema formation and tissue loss following traumatic brain injury in mice
por: Kenne, Ellinor, et al.
Publicado: (2012)

Delineating Amyloid Plaque Associated Neuronal Sphingolipids in Transgenic Alzheimer’s Disease Mice (tgArcSwe) Using MALDI Imaging Mass Spectrometry
por: Kaya, Ibrahim, et al.
Publicado: (2016)

Identification of Injury Specific Proteins in a Cell Culture Model of Traumatic Brain Injury
por: Lööv, Camilla, et al.
Publicado: (2013)

Antibody-Based In Vivo PET Imaging Detects Amyloid-β Reduction in Alzheimer Transgenic Mice After BACE-1 Inhibition
por: Meier, Silvio R., et al.
Publicado: (2018)

Functionalization of Radiolabeled Antibodies to Enhance Peripheral Clearance for High Contrast Brain Imaging
por: Schlein, Eva, et al.
Publicado: (2022)

Development of brain-penetrable antibody radioligands for in vivo PET imaging of amyloid-β and tau
por: Banka, Vinay, et al.
Publicado: (2023)

PET Imaging in Preclinical Anti-Aβ Drug Development
por: Syvänen, Stina, et al.
Publicado: (2022)

Efficient clearance of Aβ protofibrils in AβPP-transgenic mice treated with a brain-penetrating bifunctional antibody
por: Syvänen, Stina, et al.
Publicado: (2018)

Facilitated Assessment of Tissue Loss Following Traumatic Brain Injury
por: Hånell, Anders, et al.
Publicado: (2012)

(11)C-PiB and (124)I-Antibody PET Provide Differing Estimates of Brain Amyloid-β After Therapeutic Intervention
por: Meier, Silvio R., et al.
Publicado: (2022)

Cryo-EM of Aβ fibrils from mouse models find tg-APP(ArcSwe) fibrils resemble those found in patients with sporadic Alzheimer’s disease
por: Zielinski, Mara, et al.
Publicado: (2023)

Neutralization of Interleukin-1β following Diffuse Traumatic Brain Injury in the Mouse Attenuates the Loss of Mature Oligodendrocytes
por: Flygt, Johanna, et al.
Publicado: (2018)

Pretargeted Imaging beyond the Blood–Brain Barrier—Utopia or Feasible?
por: Lopes van den Broek, Sara, et al.
Publicado: (2022)

Long-term postural control in elite athletes following mild traumatic brain injury
por: Al-Husseini, Ali, et al.
Publicado: (2022)

Wide-Ranging Effects on the Brain Proteome in a Transgenic Mouse Model of Alzheimer’s Disease Following Treatment with a Brain-Targeting Somatostatin Peptide
por: Rofo, Fadi, et al.
Publicado: (2021)

Heterogeneous drug tissue binding in brain regions of rats, Alzheimer’s patients and controls: impact on translational drug development
por: Gustafsson, Sofia, et al.
Publicado: (2019)

Pyroglutamation of amyloid-βx-42 (Aβx-42) followed by Aβ1–40 deposition underlies plaque polymorphism in progressing Alzheimer's disease pathology
por: Michno, Wojciech, et al.
Publicado: (2019)

Hyperoxemia and long-term outcome after traumatic brain injury
por: Raj, Rahul, et al.
Publicado: (2013)

Long-term outcome after severe traumatic brain injury
por: Ciapetti, M, et al.
Publicado: (2014)

Long-term Consequences of Traumatic Brain Injury in Bone Metabolism
por: Bajwa, Nikita M., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_iilv9ebac2n8an1q64to1ab715