Small Fibre Neuropathy in Parkinson’s Disease: Comparison of Skin Biopsies from the More Affected and Less Affected Sides

We assessed small nerve fibre degeneration and regeneration in more and less affected sides in Parkinson’s disease (PD). Bilateral skin biopsies from 23 PD patients were immunostained for PGP9.5 for Intraepidermal Nerve Fibre Density (IENFD) and GAP-43 for mean axonal length (MAL), total epidermal (...

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Autores principales: Jeziorska, Maria, Atkinson, Andrew, Kass-Iliyya, Lewis, Kobylecki, Christopher, Gosal, David, Marshall, Andrew, Malik, Rayaz A., Silverdale, Monty
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2019
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839493/
https://www.ncbi.nlm.nih.gov/pubmed/31381529
http://dx.doi.org/10.3233/JPD-191697
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author Jeziorska, Maria
Atkinson, Andrew
Kass-Iliyya, Lewis
Kobylecki, Christopher
Gosal, David
Marshall, Andrew
Malik, Rayaz A.
Silverdale, Monty
author_facet Jeziorska, Maria
Atkinson, Andrew
Kass-Iliyya, Lewis
Kobylecki, Christopher
Gosal, David
Marshall, Andrew
Malik, Rayaz A.
Silverdale, Monty
author_sort Jeziorska, Maria
collection PubMed
description We assessed small nerve fibre degeneration and regeneration in more and less affected sides in Parkinson’s disease (PD). Bilateral skin biopsies from 23 PD patients were immunostained for PGP9.5 for Intraepidermal Nerve Fibre Density (IENFD) and GAP-43 for mean axonal length (MAL), total epidermal (TNFL) and subepidermal nerve fibre length (SKTNFL). IENFD (p < 0.001) and SKTNFL (p < 0.001) were lower, whilst MAL (p < 0.001) and TNFL (p < 0.05) were higher in more affected versus less affected side. These results suggest increased small nerve fibre degeneration accompanied by enhanced nerve regeneration on the side more affected by PD and GAP-43 usefulness in skin biopsy assessment.
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spelling pubmed-68394932019-11-20 Small Fibre Neuropathy in Parkinson’s Disease: Comparison of Skin Biopsies from the More Affected and Less Affected Sides Jeziorska, Maria Atkinson, Andrew Kass-Iliyya, Lewis Kobylecki, Christopher Gosal, David Marshall, Andrew Malik, Rayaz A. Silverdale, Monty J Parkinsons Dis Short Communication We assessed small nerve fibre degeneration and regeneration in more and less affected sides in Parkinson’s disease (PD). Bilateral skin biopsies from 23 PD patients were immunostained for PGP9.5 for Intraepidermal Nerve Fibre Density (IENFD) and GAP-43 for mean axonal length (MAL), total epidermal (TNFL) and subepidermal nerve fibre length (SKTNFL). IENFD (p < 0.001) and SKTNFL (p < 0.001) were lower, whilst MAL (p < 0.001) and TNFL (p < 0.05) were higher in more affected versus less affected side. These results suggest increased small nerve fibre degeneration accompanied by enhanced nerve regeneration on the side more affected by PD and GAP-43 usefulness in skin biopsy assessment. IOS Press 2019-10-11 /pmc/articles/PMC6839493/ /pubmed/31381529 http://dx.doi.org/10.3233/JPD-191697 Text en © 2019 – IOS Press and the authors. All rights reserved https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) License (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Short Communication
Jeziorska, Maria
Atkinson, Andrew
Kass-Iliyya, Lewis
Kobylecki, Christopher
Gosal, David
Marshall, Andrew
Malik, Rayaz A.
Silverdale, Monty
Small Fibre Neuropathy in Parkinson’s Disease: Comparison of Skin Biopsies from the More Affected and Less Affected Sides
title Small Fibre Neuropathy in Parkinson’s Disease: Comparison of Skin Biopsies from the More Affected and Less Affected Sides
title_full Small Fibre Neuropathy in Parkinson’s Disease: Comparison of Skin Biopsies from the More Affected and Less Affected Sides
title_fullStr Small Fibre Neuropathy in Parkinson’s Disease: Comparison of Skin Biopsies from the More Affected and Less Affected Sides
title_full_unstemmed Small Fibre Neuropathy in Parkinson’s Disease: Comparison of Skin Biopsies from the More Affected and Less Affected Sides
title_short Small Fibre Neuropathy in Parkinson’s Disease: Comparison of Skin Biopsies from the More Affected and Less Affected Sides
title_sort small fibre neuropathy in parkinson’s disease: comparison of skin biopsies from the more affected and less affected sides
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839493/
https://www.ncbi.nlm.nih.gov/pubmed/31381529
http://dx.doi.org/10.3233/JPD-191697
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