Molecular basis of methylation and chain-length programming in a fungal iterative highly reducing polyketide synthase

Exchange of 32 different sub-fragments of the C-methyltransferase (C-MeT), pseudo-ketoreductase (ΨKR) and ketoreductase (KR) catalytic domains of the tenellin iterative Type I polyketide synthase non ribosomal peptide synthetase (PKS-NRPS) TENS by homologous fragments from the desmethylbassianin (DM...

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Detalles Bibliográficos
Autores principales: Yang, Xiao-Long, Friedrich, Steffen, Yin, Sen, Piech, Oliver, Williams, Katherine, Simpson, Thomas J., Cox, Russell J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839510/
https://www.ncbi.nlm.nih.gov/pubmed/31803427
http://dx.doi.org/10.1039/c9sc03173a

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