Biology of IL-36 Signaling and Its Role in Systemic Inflammatory Diseases

Interleukin (IL)-36 is a member of the IL-1 superfamily and includes three agonists (IL-36α, IL-36β, and IL-36γ) and an antagonist (IL-36Ra). IL-36 agonists bind to heterodimeric receptor complexes. Then, the heterotrimer complexes signal via intracellular functional domains, binding to downstream s...

Descripción completa

Detalles Bibliográficos
Autores principales: Yuan, Zhi-Chao, Xu, Wang-Dong, Liu, Xiao-Yan, Liu, Xing-You, Huang, An-Fang, Su, Lin-Chong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839525/
https://www.ncbi.nlm.nih.gov/pubmed/31736959
http://dx.doi.org/10.3389/fimmu.2019.02532
Descripción
Sumario:Interleukin (IL)-36 is a member of the IL-1 superfamily and includes three agonists (IL-36α, IL-36β, and IL-36γ) and an antagonist (IL-36Ra). IL-36 agonists bind to heterodimeric receptor complexes. Then, the heterotrimer complexes signal via intracellular functional domains, binding to downstream signaling proteins and inducing inflammatory responses. In this review, we summarized the current knowledge about the biological role of IL-36 and its correlation with systemic inflammatory diseases. The information collected will help to increase the understanding of the potential of IL-36 and may give clues for developing novel therapeutic strategies.

Ejemplares similares