Biology of IL-36 Signaling and Its Role in Systemic Inflammatory Diseases

Interleukin (IL)-36 is a member of the IL-1 superfamily and includes three agonists (IL-36α, IL-36β, and IL-36γ) and an antagonist (IL-36Ra). IL-36 agonists bind to heterodimeric receptor complexes. Then, the heterotrimer complexes signal via intracellular functional domains, binding to downstream s...

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Autores principales: Yuan, Zhi-Chao, Xu, Wang-Dong, Liu, Xiao-Yan, Liu, Xing-You, Huang, An-Fang, Su, Lin-Chong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839525/
https://www.ncbi.nlm.nih.gov/pubmed/31736959
http://dx.doi.org/10.3389/fimmu.2019.02532
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author Yuan, Zhi-Chao
Xu, Wang-Dong
Liu, Xiao-Yan
Liu, Xing-You
Huang, An-Fang
Su, Lin-Chong
author_facet Yuan, Zhi-Chao
Xu, Wang-Dong
Liu, Xiao-Yan
Liu, Xing-You
Huang, An-Fang
Su, Lin-Chong
author_sort Yuan, Zhi-Chao
collection PubMed
description Interleukin (IL)-36 is a member of the IL-1 superfamily and includes three agonists (IL-36α, IL-36β, and IL-36γ) and an antagonist (IL-36Ra). IL-36 agonists bind to heterodimeric receptor complexes. Then, the heterotrimer complexes signal via intracellular functional domains, binding to downstream signaling proteins and inducing inflammatory responses. In this review, we summarized the current knowledge about the biological role of IL-36 and its correlation with systemic inflammatory diseases. The information collected will help to increase the understanding of the potential of IL-36 and may give clues for developing novel therapeutic strategies.
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spelling pubmed-68395252019-11-15 Biology of IL-36 Signaling and Its Role in Systemic Inflammatory Diseases Yuan, Zhi-Chao Xu, Wang-Dong Liu, Xiao-Yan Liu, Xing-You Huang, An-Fang Su, Lin-Chong Front Immunol Immunology Interleukin (IL)-36 is a member of the IL-1 superfamily and includes three agonists (IL-36α, IL-36β, and IL-36γ) and an antagonist (IL-36Ra). IL-36 agonists bind to heterodimeric receptor complexes. Then, the heterotrimer complexes signal via intracellular functional domains, binding to downstream signaling proteins and inducing inflammatory responses. In this review, we summarized the current knowledge about the biological role of IL-36 and its correlation with systemic inflammatory diseases. The information collected will help to increase the understanding of the potential of IL-36 and may give clues for developing novel therapeutic strategies. Frontiers Media S.A. 2019-10-31 /pmc/articles/PMC6839525/ /pubmed/31736959 http://dx.doi.org/10.3389/fimmu.2019.02532 Text en Copyright © 2019 Yuan, Xu, Liu, Liu, Huang and Su. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Yuan, Zhi-Chao
Xu, Wang-Dong
Liu, Xiao-Yan
Liu, Xing-You
Huang, An-Fang
Su, Lin-Chong
Biology of IL-36 Signaling and Its Role in Systemic Inflammatory Diseases
title Biology of IL-36 Signaling and Its Role in Systemic Inflammatory Diseases
title_full Biology of IL-36 Signaling and Its Role in Systemic Inflammatory Diseases
title_fullStr Biology of IL-36 Signaling and Its Role in Systemic Inflammatory Diseases
title_full_unstemmed Biology of IL-36 Signaling and Its Role in Systemic Inflammatory Diseases
title_short Biology of IL-36 Signaling and Its Role in Systemic Inflammatory Diseases
title_sort biology of il-36 signaling and its role in systemic inflammatory diseases
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839525/
https://www.ncbi.nlm.nih.gov/pubmed/31736959
http://dx.doi.org/10.3389/fimmu.2019.02532
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