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Biology of IL-36 Signaling and Its Role in Systemic Inflammatory Diseases

Interleukin (IL)-36 is a member of the IL-1 superfamily and includes three agonists (IL-36α, IL-36β, and IL-36γ) and an antagonist (IL-36Ra). IL-36 agonists bind to heterodimeric receptor complexes. Then, the heterotrimer complexes signal via intracellular functional domains, binding to downstream s...

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Detalles Bibliográficos
Autores principales:	Yuan, Zhi-Chao, Xu, Wang-Dong, Liu, Xiao-Yan, Liu, Xing-You, Huang, An-Fang, Su, Lin-Chong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839525/ https://www.ncbi.nlm.nih.gov/pubmed/31736959 http://dx.doi.org/10.3389/fimmu.2019.02532

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