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Rational design of a multifunctional molecular dye for dual-modal NIR-II/photoacoustic imaging and photothermal therapy
Small-molecule based multifunctional probes play significant roles in biomedical science and possess high clinical translational ability. However, the preparation of these promising probes without complicated synthetic procedures remains a challenging task. Herein, we rationally designed a high-perf...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Royal Society of Chemistry
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839587/ https://www.ncbi.nlm.nih.gov/pubmed/31803412 http://dx.doi.org/10.1039/c9sc03504d |
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author | Zhang, Ruiping Xu, Yuling Zhang, Yi Kim, Hyeong Seok Sharma, Amit Gao, Jing Yang, Guangfu Kim, Jong Seung Sun, Yao |
author_facet | Zhang, Ruiping Xu, Yuling Zhang, Yi Kim, Hyeong Seok Sharma, Amit Gao, Jing Yang, Guangfu Kim, Jong Seung Sun, Yao |
author_sort | Zhang, Ruiping |
collection | PubMed |
description | Small-molecule based multifunctional probes play significant roles in biomedical science and possess high clinical translational ability. However, the preparation of these promising probes without complicated synthetic procedures remains a challenging task. Herein, we rationally designed a high-performance DD–A–DD scaffold molecular dye (SYL) with an intrinsic multifunctional ability and then incorporated it into DSPE-mPEG5000 to facilely construct biocompatible NIR-II fluorescent and photoacoustic (PA) dual-modal theranostic nanoprobes (SYL NPs) (∼120 nm). In vivo studies confirmed that SYL NPs exhibited bright NIR-II fluorescence and PA signals in the tumor region with a promising signal to background ratio (S/B). Meanwhile, SYL NPs demonstrated significantly inhibited tumor growth under laser irradiation with no noticeable side effects. These promising results highlighted SYL NPs as a potential theranostic platform for cancer diagnosis (NIR-II region) and therapy. |
format | Online Article Text |
id | pubmed-6839587 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-68395872019-12-04 Rational design of a multifunctional molecular dye for dual-modal NIR-II/photoacoustic imaging and photothermal therapy Zhang, Ruiping Xu, Yuling Zhang, Yi Kim, Hyeong Seok Sharma, Amit Gao, Jing Yang, Guangfu Kim, Jong Seung Sun, Yao Chem Sci Chemistry Small-molecule based multifunctional probes play significant roles in biomedical science and possess high clinical translational ability. However, the preparation of these promising probes without complicated synthetic procedures remains a challenging task. Herein, we rationally designed a high-performance DD–A–DD scaffold molecular dye (SYL) with an intrinsic multifunctional ability and then incorporated it into DSPE-mPEG5000 to facilely construct biocompatible NIR-II fluorescent and photoacoustic (PA) dual-modal theranostic nanoprobes (SYL NPs) (∼120 nm). In vivo studies confirmed that SYL NPs exhibited bright NIR-II fluorescence and PA signals in the tumor region with a promising signal to background ratio (S/B). Meanwhile, SYL NPs demonstrated significantly inhibited tumor growth under laser irradiation with no noticeable side effects. These promising results highlighted SYL NPs as a potential theranostic platform for cancer diagnosis (NIR-II region) and therapy. Royal Society of Chemistry 2019-07-30 /pmc/articles/PMC6839587/ /pubmed/31803412 http://dx.doi.org/10.1039/c9sc03504d Text en This journal is © The Royal Society of Chemistry 2019 http://creativecommons.org/licenses/by-nc/3.0/ This article is freely available. This article is licensed under a Creative Commons Attribution Non Commercial 3.0 Unported Licence (CC BY-NC 3.0) |
spellingShingle | Chemistry Zhang, Ruiping Xu, Yuling Zhang, Yi Kim, Hyeong Seok Sharma, Amit Gao, Jing Yang, Guangfu Kim, Jong Seung Sun, Yao Rational design of a multifunctional molecular dye for dual-modal NIR-II/photoacoustic imaging and photothermal therapy |
title | Rational design of a multifunctional molecular dye for dual-modal NIR-II/photoacoustic imaging and photothermal therapy
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title_full | Rational design of a multifunctional molecular dye for dual-modal NIR-II/photoacoustic imaging and photothermal therapy
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title_fullStr | Rational design of a multifunctional molecular dye for dual-modal NIR-II/photoacoustic imaging and photothermal therapy
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title_full_unstemmed | Rational design of a multifunctional molecular dye for dual-modal NIR-II/photoacoustic imaging and photothermal therapy
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title_short | Rational design of a multifunctional molecular dye for dual-modal NIR-II/photoacoustic imaging and photothermal therapy
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title_sort | rational design of a multifunctional molecular dye for dual-modal nir-ii/photoacoustic imaging and photothermal therapy |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839587/ https://www.ncbi.nlm.nih.gov/pubmed/31803412 http://dx.doi.org/10.1039/c9sc03504d |
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