A Case of Granulomatosis with Polyangiitis (Wegener’s Granulomatosis) Presenting with Rapidly Progressive Glomerulonephritis

Granulomatosis with polyangiitis (GPA, Wegener’s granulomatosis) presenting as rapidly progressive glomerulonephritis is not uncommon. The recognition of multisystem disease involving joints, kidney, and lung is critical for diagnosing Wegener's vasculitis. Here, we report a case study of a 52-...

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Autores principales: Hasan, Md Rockyb, Sakibuzzaman, Md, Tabassum, Tahsin, Moosa, Syed Ahmad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2019
Materias:
Pulmonology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839754/
https://www.ncbi.nlm.nih.gov/pubmed/31772866
http://dx.doi.org/10.7759/cureus.5896
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author Hasan, Md Rockyb
Sakibuzzaman, Md
Tabassum, Tahsin
Moosa, Syed Ahmad
author_facet Hasan, Md Rockyb
Sakibuzzaman, Md
Tabassum, Tahsin
Moosa, Syed Ahmad
author_sort Hasan, Md Rockyb
collection PubMed
description Granulomatosis with polyangiitis (GPA, Wegener’s granulomatosis) presenting as rapidly progressive glomerulonephritis is not uncommon. The recognition of multisystem disease involving joints, kidney, and lung is critical for diagnosing Wegener's vasculitis. Here, we report a case study of a 52-year-old Bangladeshi man presented with a history of progressively worsening fever, recurrent cough, and hemoptysis. He developed renal failure within a month which was successfully treated with high-dose steroids, cyclophosphamide, and trimethoprim-sulfamethoxazole (TMP-SMX). Rapidly progressive glomerulonephritis can be a fulminant manifestation of GPA, in which case an immediate and aggressive treatment with pulse steroids, high-dose cyclophosphamide and TMP-SMX can be lifesaving.
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spelling pubmed-68397542019-11-26 A Case of Granulomatosis with Polyangiitis (Wegener’s Granulomatosis) Presenting with Rapidly Progressive Glomerulonephritis Hasan, Md Rockyb Sakibuzzaman, Md Tabassum, Tahsin Moosa, Syed Ahmad Cureus Pulmonology Granulomatosis with polyangiitis (GPA, Wegener’s granulomatosis) presenting as rapidly progressive glomerulonephritis is not uncommon. The recognition of multisystem disease involving joints, kidney, and lung is critical for diagnosing Wegener's vasculitis. Here, we report a case study of a 52-year-old Bangladeshi man presented with a history of progressively worsening fever, recurrent cough, and hemoptysis. He developed renal failure within a month which was successfully treated with high-dose steroids, cyclophosphamide, and trimethoprim-sulfamethoxazole (TMP-SMX). Rapidly progressive glomerulonephritis can be a fulminant manifestation of GPA, in which case an immediate and aggressive treatment with pulse steroids, high-dose cyclophosphamide and TMP-SMX can be lifesaving. Cureus 2019-10-12 /pmc/articles/PMC6839754/ /pubmed/31772866 http://dx.doi.org/10.7759/cureus.5896 Text en Copyright © 2019, Hasan et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Pulmonology
Hasan, Md Rockyb
Sakibuzzaman, Md
Tabassum, Tahsin
Moosa, Syed Ahmad
A Case of Granulomatosis with Polyangiitis (Wegener’s Granulomatosis) Presenting with Rapidly Progressive Glomerulonephritis
title A Case of Granulomatosis with Polyangiitis (Wegener’s Granulomatosis) Presenting with Rapidly Progressive Glomerulonephritis
title_full A Case of Granulomatosis with Polyangiitis (Wegener’s Granulomatosis) Presenting with Rapidly Progressive Glomerulonephritis
title_fullStr A Case of Granulomatosis with Polyangiitis (Wegener’s Granulomatosis) Presenting with Rapidly Progressive Glomerulonephritis
title_full_unstemmed A Case of Granulomatosis with Polyangiitis (Wegener’s Granulomatosis) Presenting with Rapidly Progressive Glomerulonephritis
title_short A Case of Granulomatosis with Polyangiitis (Wegener’s Granulomatosis) Presenting with Rapidly Progressive Glomerulonephritis
title_sort case of granulomatosis with polyangiitis (wegener’s granulomatosis) presenting with rapidly progressive glomerulonephritis
topic Pulmonology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839754/
https://www.ncbi.nlm.nih.gov/pubmed/31772866
http://dx.doi.org/10.7759/cureus.5896
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