Microbial bile salt hydrolases mediate the efficacy of faecal microbiota transplant in the treatment of recurrent Clostridioides difficile infection

OBJECTIVE: Faecal microbiota transplant (FMT) effectively treats recurrent Clostridioides difficile infection (rCDI), but its mechanisms of action remain poorly defined. Certain bile acids affect C. difficile germination or vegetative growth. We hypothesised that loss of gut microbiota-derived bile...

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Detalles Bibliográficos
Autores principales: Mullish, Benjamin H, McDonald, Julie A K, Pechlivanis, Alexandros, Allegretti, Jessica R, Kao, Dina, Barker, Grace F, Kapila, Diya, Petrof, Elaine O, Joyce, Susan A, Gahan, Cormac G M, Glegola-Madejska, Izabela, Williams, Horace R T, Holmes, Elaine, Clarke, Thomas B, Thursz, Mark R, Marchesi, Julian R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2019
Materias:
Gut Microbiota
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839797/
https://www.ncbi.nlm.nih.gov/pubmed/30816855
http://dx.doi.org/10.1136/gutjnl-2018-317842

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