ROBUST BIOMARKERS OF AGING AND THEIR BIOLOGICAL ORIGIN

The biological origin of impressive accuracy of DNA methylation clocks, the most precise currently available biological markers of aging in humans and model animals, remains largely unclear. In addition, they sometimes suffer from uncontrollable precision loss out of sample. To address these two iss...

Descripción completa

Detalles Bibliográficos
Autores principales: Podolskiy, Dmitriy, Gladyshev, Vadim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Session 625 (Symposium)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6840040/
http://dx.doi.org/10.1093/geroni/igz038.131
_version_ 1783467531585978368
author Podolskiy, Dmitriy
Podolskiy, Dmitriy
Gladyshev, Vadim
author_facet Podolskiy, Dmitriy
Podolskiy, Dmitriy
Gladyshev, Vadim
author_sort Podolskiy, Dmitriy
collection PubMed
description The biological origin of impressive accuracy of DNA methylation clocks, the most precise currently available biological markers of aging in humans and model animals, remains largely unclear. In addition, they sometimes suffer from uncontrollable precision loss out of sample. To address these two issues, we develop a novel method for constructing robust molecular markers of age based on network analysis of age-dependent omics data. The newly developed robust markers of aging in yeast, fruit fly, mouse and human are nearly free of batch effects and have a transparent biological nature related to tight control of translation-related processes and their disregulation associated with aging.
format Online
Article
Text
id pubmed-6840040
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-68400402019-11-13 ROBUST BIOMARKERS OF AGING AND THEIR BIOLOGICAL ORIGIN Podolskiy, Dmitriy Podolskiy, Dmitriy Gladyshev, Vadim Innov Aging Session 625 (Symposium) The biological origin of impressive accuracy of DNA methylation clocks, the most precise currently available biological markers of aging in humans and model animals, remains largely unclear. In addition, they sometimes suffer from uncontrollable precision loss out of sample. To address these two issues, we develop a novel method for constructing robust molecular markers of age based on network analysis of age-dependent omics data. The newly developed robust markers of aging in yeast, fruit fly, mouse and human are nearly free of batch effects and have a transparent biological nature related to tight control of translation-related processes and their disregulation associated with aging. Oxford University Press 2019-11-08 /pmc/articles/PMC6840040/ http://dx.doi.org/10.1093/geroni/igz038.131 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of The Gerontological Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Session 625 (Symposium)
Podolskiy, Dmitriy
Podolskiy, Dmitriy
Gladyshev, Vadim
ROBUST BIOMARKERS OF AGING AND THEIR BIOLOGICAL ORIGIN
title ROBUST BIOMARKERS OF AGING AND THEIR BIOLOGICAL ORIGIN
title_full ROBUST BIOMARKERS OF AGING AND THEIR BIOLOGICAL ORIGIN
title_fullStr ROBUST BIOMARKERS OF AGING AND THEIR BIOLOGICAL ORIGIN
title_full_unstemmed ROBUST BIOMARKERS OF AGING AND THEIR BIOLOGICAL ORIGIN
title_short ROBUST BIOMARKERS OF AGING AND THEIR BIOLOGICAL ORIGIN
title_sort robust biomarkers of aging and their biological origin
topic Session 625 (Symposium)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6840040/
http://dx.doi.org/10.1093/geroni/igz038.131
work_keys_str_mv AT podolskiydmitriy robustbiomarkersofagingandtheirbiologicalorigin
AT podolskiydmitriy robustbiomarkersofagingandtheirbiologicalorigin
AT gladyshevvadim robustbiomarkersofagingandtheirbiologicalorigin

Ejemplares similares