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UTILITY OF EXECUTIVE FUNCTION TO IDENTIFY EARLY COGNITIVE IMPAIRMENT IN AFRICAN AMERICANS

Within diverse cohorts, African Americans (AA) demonstrate higher rates of Alzheimer’s dementia (AD) and Alzheimer’s dementia combined with multiple comorbid conditions. AA are also two times more likely to develop late-onset AD than whites and less likely to be diagnosed. Yet, our understanding of...

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Autores principales: Garrett, Stephanie, Goldstein, Felicia C, Chen, Yunyun, Easley, Kirk, McDaniel, Darius, Lea, Janice, Thomas, Tiffany, Saleh, Sabria, Hajjar, Ihab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6840461/
http://dx.doi.org/10.1093/geroni/igz038.048
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author Garrett, Stephanie
Goldstein, Felicia C
Chen, Yunyun
Easley, Kirk
McDaniel, Darius
Lea, Janice
Thomas, Tiffany
Saleh, Sabria
Hajjar, Ihab
author_facet Garrett, Stephanie
Goldstein, Felicia C
Chen, Yunyun
Easley, Kirk
McDaniel, Darius
Lea, Janice
Thomas, Tiffany
Saleh, Sabria
Hajjar, Ihab
author_sort Garrett, Stephanie
collection PubMed
description Within diverse cohorts, African Americans (AA) demonstrate higher rates of Alzheimer’s dementia (AD) and Alzheimer’s dementia combined with multiple comorbid conditions. AA are also two times more likely to develop late-onset AD than whites and less likely to be diagnosed. Yet, our understanding of this disparity in cognition remains limited. Cognitive impairment (CI) and dementia are both underdiagnosed and underreported in primary care patients. The lack of early detection of cognitive and functional decline in high risk populations results in failure to provide care and interventions to members of vulnerable groups. This talk will focus on research that seeks to identify a more sensitive cognitive marker for early identification of cognitive impairment for AA and advances this objective by linking the cognitive marker to AD cerebral spinal fluid biomarkers (Aβ1-42, p-tau) and testing whether this association differs between AA and whites.
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spelling pubmed-68404612019-11-14 UTILITY OF EXECUTIVE FUNCTION TO IDENTIFY EARLY COGNITIVE IMPAIRMENT IN AFRICAN AMERICANS Garrett, Stephanie Goldstein, Felicia C Chen, Yunyun Easley, Kirk McDaniel, Darius Lea, Janice Thomas, Tiffany Saleh, Sabria Hajjar, Ihab Innov Aging Session 545 (Symposium) Within diverse cohorts, African Americans (AA) demonstrate higher rates of Alzheimer’s dementia (AD) and Alzheimer’s dementia combined with multiple comorbid conditions. AA are also two times more likely to develop late-onset AD than whites and less likely to be diagnosed. Yet, our understanding of this disparity in cognition remains limited. Cognitive impairment (CI) and dementia are both underdiagnosed and underreported in primary care patients. The lack of early detection of cognitive and functional decline in high risk populations results in failure to provide care and interventions to members of vulnerable groups. This talk will focus on research that seeks to identify a more sensitive cognitive marker for early identification of cognitive impairment for AA and advances this objective by linking the cognitive marker to AD cerebral spinal fluid biomarkers (Aβ1-42, p-tau) and testing whether this association differs between AA and whites. Oxford University Press 2019-11-08 /pmc/articles/PMC6840461/ http://dx.doi.org/10.1093/geroni/igz038.048 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of The Gerontological Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Session 545 (Symposium)
Garrett, Stephanie
Goldstein, Felicia C
Chen, Yunyun
Easley, Kirk
McDaniel, Darius
Lea, Janice
Thomas, Tiffany
Saleh, Sabria
Hajjar, Ihab
UTILITY OF EXECUTIVE FUNCTION TO IDENTIFY EARLY COGNITIVE IMPAIRMENT IN AFRICAN AMERICANS
title UTILITY OF EXECUTIVE FUNCTION TO IDENTIFY EARLY COGNITIVE IMPAIRMENT IN AFRICAN AMERICANS
title_full UTILITY OF EXECUTIVE FUNCTION TO IDENTIFY EARLY COGNITIVE IMPAIRMENT IN AFRICAN AMERICANS
title_fullStr UTILITY OF EXECUTIVE FUNCTION TO IDENTIFY EARLY COGNITIVE IMPAIRMENT IN AFRICAN AMERICANS
title_full_unstemmed UTILITY OF EXECUTIVE FUNCTION TO IDENTIFY EARLY COGNITIVE IMPAIRMENT IN AFRICAN AMERICANS
title_short UTILITY OF EXECUTIVE FUNCTION TO IDENTIFY EARLY COGNITIVE IMPAIRMENT IN AFRICAN AMERICANS
title_sort utility of executive function to identify early cognitive impairment in african americans
topic Session 545 (Symposium)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6840461/
http://dx.doi.org/10.1093/geroni/igz038.048
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