INTEGRATING FRAILTY AND COGNITIVE PHENOTYPES: THEORY, MEASUREMENT, APPLICATIONS

The fact that frailty and cognitive impairment are associated and often coexist in older adults has led to the popular view of expanding the definition of frailty to include cognitive impairment. However, there is great variability in approaches to and assumptions regarding the integrated phenotypes...

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Detalles Bibliográficos
Autores principales: Xue, Qianli, Buta, Brian, Ma, Lina, Ge, Meiling, carlson, Michelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Session 2095 (Symposium)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6840668/
http://dx.doi.org/10.1093/geroni/igz038.1464
Descripción
Sumario:The fact that frailty and cognitive impairment are associated and often coexist in older adults has led to the popular view of expanding the definition of frailty to include cognitive impairment. However, there is great variability in approaches to and assumptions regarding the integrated phenotypes of physical frailty and cognitive impairment. By reviewing the theoretical underpinnings of three integrated phenotypes of physical and cognitive impairments, this talk advocates the incorporation of biological theories in phenotype development that helps determine shared and distinct pathways in the progression to physical and cognitive impairments.

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