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LONGITUDINAL ASSOCIATION BETWEEN SERUM 25 HYDROXY VITAMIN D AND COGNITIVE FUNCTION AMONG ICELANDIC OLDER ADULTS

Studies have indicated that low levels of serum 25 hydroxy vitamin D (25OHD) are associated with lower cognitive function among older adults while longitudinal studies have revealed controversial results. The aim was to investigate the longitudinal associations between 25OHD and cognitive function a...

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Autores principales: Eymundsdottir, Hrafnhildur, Chang, Milan, Geirsdottir, Olof, Jonsdottir, Maria, Jonsson, Palmi V, Gudnason, Vilmundur, Ramel, Alfons
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6840848/
http://dx.doi.org/10.1093/geroni/igz038.1799
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author Eymundsdottir, Hrafnhildur
Chang, Milan
Geirsdottir, Olof
Jonsdottir, Maria
Jonsson, Palmi V
Gudnason, Vilmundur
Ramel, Alfons
author_facet Eymundsdottir, Hrafnhildur
Chang, Milan
Geirsdottir, Olof
Jonsdottir, Maria
Jonsson, Palmi V
Gudnason, Vilmundur
Ramel, Alfons
author_sort Eymundsdottir, Hrafnhildur
collection PubMed
description Studies have indicated that low levels of serum 25 hydroxy vitamin D (25OHD) are associated with lower cognitive function among older adults while longitudinal studies have revealed controversial results. The aim was to investigate the longitudinal associations between 25OHD and cognitive function among older adults with 5-years follow up. The Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study (N=3411) assessed cognitive function measuring memory function, speed of processing and executive function. 25OHD was measured using the Liaison chemiluminescence immunoassay and used as a continuous variable. Multivariate linear analysis, adjusting for numerous confounding factors, was used to calculate the longitudinal associations. All analyses were performed separated by gender. There was a high tendency for low levels of 25OHD i.e. 29.6% men and 37.7% women had hypovitaminosis D (<50 nmol/l). Both men and women had significantly lower scores in all aspects of cognitive function at the follow-up time period. Unadjusted correlations between 25OHD and cognitive functions showed a stronger correlation for women, whereas women had lower scores in all aspects of cognitive function associated with low 25OHD. After adjusting for potential confounders, e.g. age, education, lifestyle and health-related factors, 25OHD and cognitive function were not significantly associated. Observational studies indicate that lower levels of vitamin D are associated with lower cognitive function. Intervention studies are yet to show a clear benefit from vitamin D supplementation. More longitudinal- and interventional studies, with longer follow-up duration, are needed.
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spelling pubmed-68408482019-11-15 LONGITUDINAL ASSOCIATION BETWEEN SERUM 25 HYDROXY VITAMIN D AND COGNITIVE FUNCTION AMONG ICELANDIC OLDER ADULTS Eymundsdottir, Hrafnhildur Chang, Milan Geirsdottir, Olof Jonsdottir, Maria Jonsson, Palmi V Gudnason, Vilmundur Ramel, Alfons Innov Aging Session 2370 (Poster) Studies have indicated that low levels of serum 25 hydroxy vitamin D (25OHD) are associated with lower cognitive function among older adults while longitudinal studies have revealed controversial results. The aim was to investigate the longitudinal associations between 25OHD and cognitive function among older adults with 5-years follow up. The Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study (N=3411) assessed cognitive function measuring memory function, speed of processing and executive function. 25OHD was measured using the Liaison chemiluminescence immunoassay and used as a continuous variable. Multivariate linear analysis, adjusting for numerous confounding factors, was used to calculate the longitudinal associations. All analyses were performed separated by gender. There was a high tendency for low levels of 25OHD i.e. 29.6% men and 37.7% women had hypovitaminosis D (<50 nmol/l). Both men and women had significantly lower scores in all aspects of cognitive function at the follow-up time period. Unadjusted correlations between 25OHD and cognitive functions showed a stronger correlation for women, whereas women had lower scores in all aspects of cognitive function associated with low 25OHD. After adjusting for potential confounders, e.g. age, education, lifestyle and health-related factors, 25OHD and cognitive function were not significantly associated. Observational studies indicate that lower levels of vitamin D are associated with lower cognitive function. Intervention studies are yet to show a clear benefit from vitamin D supplementation. More longitudinal- and interventional studies, with longer follow-up duration, are needed. Oxford University Press 2019-11-08 /pmc/articles/PMC6840848/ http://dx.doi.org/10.1093/geroni/igz038.1799 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of The Gerontological Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Session 2370 (Poster)
Eymundsdottir, Hrafnhildur
Chang, Milan
Geirsdottir, Olof
Jonsdottir, Maria
Jonsson, Palmi V
Gudnason, Vilmundur
Ramel, Alfons
LONGITUDINAL ASSOCIATION BETWEEN SERUM 25 HYDROXY VITAMIN D AND COGNITIVE FUNCTION AMONG ICELANDIC OLDER ADULTS
title LONGITUDINAL ASSOCIATION BETWEEN SERUM 25 HYDROXY VITAMIN D AND COGNITIVE FUNCTION AMONG ICELANDIC OLDER ADULTS
title_full LONGITUDINAL ASSOCIATION BETWEEN SERUM 25 HYDROXY VITAMIN D AND COGNITIVE FUNCTION AMONG ICELANDIC OLDER ADULTS
title_fullStr LONGITUDINAL ASSOCIATION BETWEEN SERUM 25 HYDROXY VITAMIN D AND COGNITIVE FUNCTION AMONG ICELANDIC OLDER ADULTS
title_full_unstemmed LONGITUDINAL ASSOCIATION BETWEEN SERUM 25 HYDROXY VITAMIN D AND COGNITIVE FUNCTION AMONG ICELANDIC OLDER ADULTS
title_short LONGITUDINAL ASSOCIATION BETWEEN SERUM 25 HYDROXY VITAMIN D AND COGNITIVE FUNCTION AMONG ICELANDIC OLDER ADULTS
title_sort longitudinal association between serum 25 hydroxy vitamin d and cognitive function among icelandic older adults
topic Session 2370 (Poster)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6840848/
http://dx.doi.org/10.1093/geroni/igz038.1799
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