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LONGITUDINAL ASSOCIATION BETWEEN SERUM 25 HYDROXY VITAMIN D AND COGNITIVE FUNCTION AMONG ICELANDIC OLDER ADULTS
Studies have indicated that low levels of serum 25 hydroxy vitamin D (25OHD) are associated with lower cognitive function among older adults while longitudinal studies have revealed controversial results. The aim was to investigate the longitudinal associations between 25OHD and cognitive function a...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6840848/ http://dx.doi.org/10.1093/geroni/igz038.1799 |
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author | Eymundsdottir, Hrafnhildur Chang, Milan Geirsdottir, Olof Jonsdottir, Maria Jonsson, Palmi V Gudnason, Vilmundur Ramel, Alfons |
author_facet | Eymundsdottir, Hrafnhildur Chang, Milan Geirsdottir, Olof Jonsdottir, Maria Jonsson, Palmi V Gudnason, Vilmundur Ramel, Alfons |
author_sort | Eymundsdottir, Hrafnhildur |
collection | PubMed |
description | Studies have indicated that low levels of serum 25 hydroxy vitamin D (25OHD) are associated with lower cognitive function among older adults while longitudinal studies have revealed controversial results. The aim was to investigate the longitudinal associations between 25OHD and cognitive function among older adults with 5-years follow up. The Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study (N=3411) assessed cognitive function measuring memory function, speed of processing and executive function. 25OHD was measured using the Liaison chemiluminescence immunoassay and used as a continuous variable. Multivariate linear analysis, adjusting for numerous confounding factors, was used to calculate the longitudinal associations. All analyses were performed separated by gender. There was a high tendency for low levels of 25OHD i.e. 29.6% men and 37.7% women had hypovitaminosis D (<50 nmol/l). Both men and women had significantly lower scores in all aspects of cognitive function at the follow-up time period. Unadjusted correlations between 25OHD and cognitive functions showed a stronger correlation for women, whereas women had lower scores in all aspects of cognitive function associated with low 25OHD. After adjusting for potential confounders, e.g. age, education, lifestyle and health-related factors, 25OHD and cognitive function were not significantly associated. Observational studies indicate that lower levels of vitamin D are associated with lower cognitive function. Intervention studies are yet to show a clear benefit from vitamin D supplementation. More longitudinal- and interventional studies, with longer follow-up duration, are needed. |
format | Online Article Text |
id | pubmed-6840848 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-68408482019-11-15 LONGITUDINAL ASSOCIATION BETWEEN SERUM 25 HYDROXY VITAMIN D AND COGNITIVE FUNCTION AMONG ICELANDIC OLDER ADULTS Eymundsdottir, Hrafnhildur Chang, Milan Geirsdottir, Olof Jonsdottir, Maria Jonsson, Palmi V Gudnason, Vilmundur Ramel, Alfons Innov Aging Session 2370 (Poster) Studies have indicated that low levels of serum 25 hydroxy vitamin D (25OHD) are associated with lower cognitive function among older adults while longitudinal studies have revealed controversial results. The aim was to investigate the longitudinal associations between 25OHD and cognitive function among older adults with 5-years follow up. The Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study (N=3411) assessed cognitive function measuring memory function, speed of processing and executive function. 25OHD was measured using the Liaison chemiluminescence immunoassay and used as a continuous variable. Multivariate linear analysis, adjusting for numerous confounding factors, was used to calculate the longitudinal associations. All analyses were performed separated by gender. There was a high tendency for low levels of 25OHD i.e. 29.6% men and 37.7% women had hypovitaminosis D (<50 nmol/l). Both men and women had significantly lower scores in all aspects of cognitive function at the follow-up time period. Unadjusted correlations between 25OHD and cognitive functions showed a stronger correlation for women, whereas women had lower scores in all aspects of cognitive function associated with low 25OHD. After adjusting for potential confounders, e.g. age, education, lifestyle and health-related factors, 25OHD and cognitive function were not significantly associated. Observational studies indicate that lower levels of vitamin D are associated with lower cognitive function. Intervention studies are yet to show a clear benefit from vitamin D supplementation. More longitudinal- and interventional studies, with longer follow-up duration, are needed. Oxford University Press 2019-11-08 /pmc/articles/PMC6840848/ http://dx.doi.org/10.1093/geroni/igz038.1799 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of The Gerontological Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Session 2370 (Poster) Eymundsdottir, Hrafnhildur Chang, Milan Geirsdottir, Olof Jonsdottir, Maria Jonsson, Palmi V Gudnason, Vilmundur Ramel, Alfons LONGITUDINAL ASSOCIATION BETWEEN SERUM 25 HYDROXY VITAMIN D AND COGNITIVE FUNCTION AMONG ICELANDIC OLDER ADULTS |
title | LONGITUDINAL ASSOCIATION BETWEEN SERUM 25 HYDROXY VITAMIN D AND COGNITIVE FUNCTION AMONG ICELANDIC OLDER ADULTS |
title_full | LONGITUDINAL ASSOCIATION BETWEEN SERUM 25 HYDROXY VITAMIN D AND COGNITIVE FUNCTION AMONG ICELANDIC OLDER ADULTS |
title_fullStr | LONGITUDINAL ASSOCIATION BETWEEN SERUM 25 HYDROXY VITAMIN D AND COGNITIVE FUNCTION AMONG ICELANDIC OLDER ADULTS |
title_full_unstemmed | LONGITUDINAL ASSOCIATION BETWEEN SERUM 25 HYDROXY VITAMIN D AND COGNITIVE FUNCTION AMONG ICELANDIC OLDER ADULTS |
title_short | LONGITUDINAL ASSOCIATION BETWEEN SERUM 25 HYDROXY VITAMIN D AND COGNITIVE FUNCTION AMONG ICELANDIC OLDER ADULTS |
title_sort | longitudinal association between serum 25 hydroxy vitamin d and cognitive function among icelandic older adults |
topic | Session 2370 (Poster) |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6840848/ http://dx.doi.org/10.1093/geroni/igz038.1799 |
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