TARGETING THE MTOR NETWORK TO MAXIMIZE HEALTHSPAN

The mechanistic target of rapamycin (mTOR) is a key nutrient and growth factor-responsive pathway that has emerged as a central regulator of aging. Inhibition of mTOR complex I in particular has been found to increase lifespan and improve functional declines during aging in yeast, worms, flies, and...

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Detalles Bibliográficos
Autor principal: Perez, Viviana I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Session 1520 (Symposium)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6840921/
http://dx.doi.org/10.1093/geroni/igz038.1349
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author Perez, Viviana I
author_facet Perez, Viviana I
author_sort Perez, Viviana I
collection PubMed
description The mechanistic target of rapamycin (mTOR) is a key nutrient and growth factor-responsive pathway that has emerged as a central regulator of aging. Inhibition of mTOR complex I in particular has been found to increase lifespan and improve functional declines during aging in yeast, worms, flies, and mice. Recently clinical studies have provided the first evidence that similar effects may be achievable in pet dogs and in elderly people. This session will focus on new discoveries related to mTOR signaling and aging.
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spelling pubmed-68409212019-11-15 TARGETING THE MTOR NETWORK TO MAXIMIZE HEALTHSPAN Perez, Viviana I Innov Aging Session 1520 (Symposium) The mechanistic target of rapamycin (mTOR) is a key nutrient and growth factor-responsive pathway that has emerged as a central regulator of aging. Inhibition of mTOR complex I in particular has been found to increase lifespan and improve functional declines during aging in yeast, worms, flies, and mice. Recently clinical studies have provided the first evidence that similar effects may be achievable in pet dogs and in elderly people. This session will focus on new discoveries related to mTOR signaling and aging. Oxford University Press 2019-11-08 /pmc/articles/PMC6840921/ http://dx.doi.org/10.1093/geroni/igz038.1349 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of The Gerontological Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Session 1520 (Symposium)
Perez, Viviana I
TARGETING THE MTOR NETWORK TO MAXIMIZE HEALTHSPAN
title TARGETING THE MTOR NETWORK TO MAXIMIZE HEALTHSPAN
title_full TARGETING THE MTOR NETWORK TO MAXIMIZE HEALTHSPAN
title_fullStr TARGETING THE MTOR NETWORK TO MAXIMIZE HEALTHSPAN
title_full_unstemmed TARGETING THE MTOR NETWORK TO MAXIMIZE HEALTHSPAN
title_short TARGETING THE MTOR NETWORK TO MAXIMIZE HEALTHSPAN
title_sort targeting the mtor network to maximize healthspan
topic Session 1520 (Symposium)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6840921/
http://dx.doi.org/10.1093/geroni/igz038.1349
work_keys_str_mv AT perezvivianai targetingthemtornetworktomaximizehealthspan

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