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NOVEL METHIONINE-RELATED INTERVENTIONS THAT CONFER HEALTHSPAN BENEFITS TO YEAST AND RODENTS

Methionine restriction (MR) is one of only a few dietary manipulations known to robustly extend healthspan in mammals. Methionine-restricted rodents are up to 45% longer-lived than control-fed littermates and a number of studies suggest that humans may also benefit from MR. While a methionine-restri...

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Autores principales: Johnson, Jay E, Plummer, Jason D, Postnikoff, Spike D, Tyler, Jessica K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6841398/
http://dx.doi.org/10.1093/geroni/igz038.263
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author Johnson, Jay E
Plummer, Jason D
Postnikoff, Spike D
Tyler, Jessica K
Johnson, Jay E
author_facet Johnson, Jay E
Plummer, Jason D
Postnikoff, Spike D
Tyler, Jessica K
Johnson, Jay E
author_sort Johnson, Jay E
collection PubMed
description Methionine restriction (MR) is one of only a few dietary manipulations known to robustly extend healthspan in mammals. Methionine-restricted rodents are up to 45% longer-lived than control-fed littermates and a number of studies suggest that humans may also benefit from MR. While a methionine-restricted human diet is technically feasible, compliance to such a regimen might not be practical or desirable. Therefore, an important goal is to identify and/or develop more facile dietary interventions, or preferably, pharmacological agents that mimic MR. Towards this end, we have made use of the yeast chronological lifespan and replicative lifespan assays, which serve as models of aging in quiescent and mitotic cells, respectively. Importantly, our lab and others have demonstrated that MR dramatically extends yeast lifespan. Here we show work aimed at developing novel MR-like interventions that extend yeast lifespan, as well as preliminary data demonstrating that such interventions significantly improve the healthspan of mice.
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spelling pubmed-68413982019-11-15 NOVEL METHIONINE-RELATED INTERVENTIONS THAT CONFER HEALTHSPAN BENEFITS TO YEAST AND RODENTS Johnson, Jay E Plummer, Jason D Postnikoff, Spike D Tyler, Jessica K Johnson, Jay E Innov Aging Session 765 (Symposium) Methionine restriction (MR) is one of only a few dietary manipulations known to robustly extend healthspan in mammals. Methionine-restricted rodents are up to 45% longer-lived than control-fed littermates and a number of studies suggest that humans may also benefit from MR. While a methionine-restricted human diet is technically feasible, compliance to such a regimen might not be practical or desirable. Therefore, an important goal is to identify and/or develop more facile dietary interventions, or preferably, pharmacological agents that mimic MR. Towards this end, we have made use of the yeast chronological lifespan and replicative lifespan assays, which serve as models of aging in quiescent and mitotic cells, respectively. Importantly, our lab and others have demonstrated that MR dramatically extends yeast lifespan. Here we show work aimed at developing novel MR-like interventions that extend yeast lifespan, as well as preliminary data demonstrating that such interventions significantly improve the healthspan of mice. Oxford University Press 2019-11-08 /pmc/articles/PMC6841398/ http://dx.doi.org/10.1093/geroni/igz038.263 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of The Gerontological Society of America. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Session 765 (Symposium)
Johnson, Jay E
Plummer, Jason D
Postnikoff, Spike D
Tyler, Jessica K
Johnson, Jay E
NOVEL METHIONINE-RELATED INTERVENTIONS THAT CONFER HEALTHSPAN BENEFITS TO YEAST AND RODENTS
title NOVEL METHIONINE-RELATED INTERVENTIONS THAT CONFER HEALTHSPAN BENEFITS TO YEAST AND RODENTS
title_full NOVEL METHIONINE-RELATED INTERVENTIONS THAT CONFER HEALTHSPAN BENEFITS TO YEAST AND RODENTS
title_fullStr NOVEL METHIONINE-RELATED INTERVENTIONS THAT CONFER HEALTHSPAN BENEFITS TO YEAST AND RODENTS
title_full_unstemmed NOVEL METHIONINE-RELATED INTERVENTIONS THAT CONFER HEALTHSPAN BENEFITS TO YEAST AND RODENTS
title_short NOVEL METHIONINE-RELATED INTERVENTIONS THAT CONFER HEALTHSPAN BENEFITS TO YEAST AND RODENTS
title_sort novel methionine-related interventions that confer healthspan benefits to yeast and rodents
topic Session 765 (Symposium)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6841398/
http://dx.doi.org/10.1093/geroni/igz038.263
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