Cav2.3 channels contribute to dopaminergic neuron loss in a model of Parkinson’s disease

Degeneration of dopaminergic neurons in the substantia nigra causes the motor symptoms of Parkinson’s disease. The mechanisms underlying this age-dependent and region-selective neurodegeneration remain unclear. Here we identify Cav2.3 channels as regulators of nigral neuronal viability. Cav2.3 trans...

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Detalles Bibliográficos
Autores principales: Benkert, Julia, Hess, Simon, Roy, Shoumik, Beccano-Kelly, Dayne, Wiederspohn, Nicole, Duda, Johanna, Simons, Carsten, Patil, Komal, Gaifullina, Aisylu, Mannal, Nadja, Dragicevic, Elena, Spaich, Desirée, Müller, Sonja, Nemeth, Julia, Hollmann, Helene, Deuter, Nora, Mousba, Yassine, Kubisch, Christian, Poetschke, Christina, Striessnig, Joerg, Pongs, Olaf, Schneider, Toni, Wade-Martins, Richard, Patel, Sandip, Parlato, Rosanna, Frank, Tobias, Kloppenburg, Peter, Liss, Birgit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6841684/
https://www.ncbi.nlm.nih.gov/pubmed/31704946
http://dx.doi.org/10.1038/s41467-019-12834-x

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