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4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects

Activated macrophages switch from oxidative phosphorylation to aerobic glycolysis, similar to the Warburg effect, presenting a potential therapeutic target in inflammatory disease. The endogenous metabolite itaconate has been reported to regulate macrophage function, but its precise mechanism is not...

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Detalles Bibliográficos
Autores principales:	Liao, Shan-Ting, Han, Chao, Xu, Ding-Qiao, Fu, Xiao-Wei, Wang, Jun-Song, Kong, Ling-Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6841710/ https://www.ncbi.nlm.nih.gov/pubmed/31704924 http://dx.doi.org/10.1038/s41467-019-13078-5

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