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Reduced activity and connectivity of left amygdala in patients with schizophrenia treated with clozapine or olanzapine
Obsessive–compulsive symptoms (OCS) in patients with schizophrenia are a common co-occurring condition, often associated with additional impairments. A subgroup of these patients develops OCS during treatment with second-generation antipsychotics (SGAs), most importantly clozapine and olanzapine. So...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6841919/ https://www.ncbi.nlm.nih.gov/pubmed/30539230 http://dx.doi.org/10.1007/s00406-018-0965-4 |
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author | Mier, Daniela Schirmbeck, Frederike Stoessel, Gabriela Esslinger, Christine Rausch, Franziska Englisch, Susanne Eisenacher, Sarah de Haan, Lieuwe Meyer-Lindenberg, Andreas Kirsch, Peter Zink, Mathias |
author_facet | Mier, Daniela Schirmbeck, Frederike Stoessel, Gabriela Esslinger, Christine Rausch, Franziska Englisch, Susanne Eisenacher, Sarah de Haan, Lieuwe Meyer-Lindenberg, Andreas Kirsch, Peter Zink, Mathias |
author_sort | Mier, Daniela |
collection | PubMed |
description | Obsessive–compulsive symptoms (OCS) in patients with schizophrenia are a common co-occurring condition, often associated with additional impairments. A subgroup of these patients develops OCS during treatment with second-generation antipsychotics (SGAs), most importantly clozapine and olanzapine. So far, little is known about possible neural mechanism of these SGAs, which seem to aggravate or induce OCS. To investigate the role of SGA treatment on neural activation and connectivity during emotional processing, patients were stratified according to their monotherapy into two groups (group I: clozapine or olanzapine, n = 20; group II: amisulpride or aripiprazole, n = 20). We used an fMRI approach, applying an implicit emotion recognition task. Group comparisons showed significantly higher frequency and severity of comorbid OCS in group I than group II. Task specific activation was attenuated in group I in the left amygdala. Furthermore, functional connectivity from left amygdala to right ventral striatum was reduced in group I. Reduced amygdala activation was associated with OCS severity. Recent literature suggests an involvement of an amygdala–cortico–striatal network in the pathogenesis of obsessive–compulsive disorder. The observed differential activation and connectivity pattern of the amygdala might thus indicate a neural mechanism for the development of SGA-associated OCS in patients with schizophrenia. Further neurobiological research and interventional studies are needed for causal inferences. |
format | Online Article Text |
id | pubmed-6841919 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-68419192019-11-22 Reduced activity and connectivity of left amygdala in patients with schizophrenia treated with clozapine or olanzapine Mier, Daniela Schirmbeck, Frederike Stoessel, Gabriela Esslinger, Christine Rausch, Franziska Englisch, Susanne Eisenacher, Sarah de Haan, Lieuwe Meyer-Lindenberg, Andreas Kirsch, Peter Zink, Mathias Eur Arch Psychiatry Clin Neurosci Original Paper Obsessive–compulsive symptoms (OCS) in patients with schizophrenia are a common co-occurring condition, often associated with additional impairments. A subgroup of these patients develops OCS during treatment with second-generation antipsychotics (SGAs), most importantly clozapine and olanzapine. So far, little is known about possible neural mechanism of these SGAs, which seem to aggravate or induce OCS. To investigate the role of SGA treatment on neural activation and connectivity during emotional processing, patients were stratified according to their monotherapy into two groups (group I: clozapine or olanzapine, n = 20; group II: amisulpride or aripiprazole, n = 20). We used an fMRI approach, applying an implicit emotion recognition task. Group comparisons showed significantly higher frequency and severity of comorbid OCS in group I than group II. Task specific activation was attenuated in group I in the left amygdala. Furthermore, functional connectivity from left amygdala to right ventral striatum was reduced in group I. Reduced amygdala activation was associated with OCS severity. Recent literature suggests an involvement of an amygdala–cortico–striatal network in the pathogenesis of obsessive–compulsive disorder. The observed differential activation and connectivity pattern of the amygdala might thus indicate a neural mechanism for the development of SGA-associated OCS in patients with schizophrenia. Further neurobiological research and interventional studies are needed for causal inferences. Springer Berlin Heidelberg 2018-12-11 2019 /pmc/articles/PMC6841919/ /pubmed/30539230 http://dx.doi.org/10.1007/s00406-018-0965-4 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Original Paper Mier, Daniela Schirmbeck, Frederike Stoessel, Gabriela Esslinger, Christine Rausch, Franziska Englisch, Susanne Eisenacher, Sarah de Haan, Lieuwe Meyer-Lindenberg, Andreas Kirsch, Peter Zink, Mathias Reduced activity and connectivity of left amygdala in patients with schizophrenia treated with clozapine or olanzapine |
title | Reduced activity and connectivity of left amygdala in patients with schizophrenia treated with clozapine or olanzapine |
title_full | Reduced activity and connectivity of left amygdala in patients with schizophrenia treated with clozapine or olanzapine |
title_fullStr | Reduced activity and connectivity of left amygdala in patients with schizophrenia treated with clozapine or olanzapine |
title_full_unstemmed | Reduced activity and connectivity of left amygdala in patients with schizophrenia treated with clozapine or olanzapine |
title_short | Reduced activity and connectivity of left amygdala in patients with schizophrenia treated with clozapine or olanzapine |
title_sort | reduced activity and connectivity of left amygdala in patients with schizophrenia treated with clozapine or olanzapine |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6841919/ https://www.ncbi.nlm.nih.gov/pubmed/30539230 http://dx.doi.org/10.1007/s00406-018-0965-4 |
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