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Reduced activity and connectivity of left amygdala in patients with schizophrenia treated with clozapine or olanzapine

Obsessive–compulsive symptoms (OCS) in patients with schizophrenia are a common co-occurring condition, often associated with additional impairments. A subgroup of these patients develops OCS during treatment with second-generation antipsychotics (SGAs), most importantly clozapine and olanzapine. So...

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Autores principales: Mier, Daniela, Schirmbeck, Frederike, Stoessel, Gabriela, Esslinger, Christine, Rausch, Franziska, Englisch, Susanne, Eisenacher, Sarah, de Haan, Lieuwe, Meyer-Lindenberg, Andreas, Kirsch, Peter, Zink, Mathias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6841919/
https://www.ncbi.nlm.nih.gov/pubmed/30539230
http://dx.doi.org/10.1007/s00406-018-0965-4
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author Mier, Daniela
Schirmbeck, Frederike
Stoessel, Gabriela
Esslinger, Christine
Rausch, Franziska
Englisch, Susanne
Eisenacher, Sarah
de Haan, Lieuwe
Meyer-Lindenberg, Andreas
Kirsch, Peter
Zink, Mathias
author_facet Mier, Daniela
Schirmbeck, Frederike
Stoessel, Gabriela
Esslinger, Christine
Rausch, Franziska
Englisch, Susanne
Eisenacher, Sarah
de Haan, Lieuwe
Meyer-Lindenberg, Andreas
Kirsch, Peter
Zink, Mathias
author_sort Mier, Daniela
collection PubMed
description Obsessive–compulsive symptoms (OCS) in patients with schizophrenia are a common co-occurring condition, often associated with additional impairments. A subgroup of these patients develops OCS during treatment with second-generation antipsychotics (SGAs), most importantly clozapine and olanzapine. So far, little is known about possible neural mechanism of these SGAs, which seem to aggravate or induce OCS. To investigate the role of SGA treatment on neural activation and connectivity during emotional processing, patients were stratified according to their monotherapy into two groups (group I: clozapine or olanzapine, n = 20; group II: amisulpride or aripiprazole, n = 20). We used an fMRI approach, applying an implicit emotion recognition task. Group comparisons showed significantly higher frequency and severity of comorbid OCS in group I than group II. Task specific activation was attenuated in group I in the left amygdala. Furthermore, functional connectivity from left amygdala to right ventral striatum was reduced in group I. Reduced amygdala activation was associated with OCS severity. Recent literature suggests an involvement of an amygdala–cortico–striatal network in the pathogenesis of obsessive–compulsive disorder. The observed differential activation and connectivity pattern of the amygdala might thus indicate a neural mechanism for the development of SGA-associated OCS in patients with schizophrenia. Further neurobiological research and interventional studies are needed for causal inferences.
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spelling pubmed-68419192019-11-22 Reduced activity and connectivity of left amygdala in patients with schizophrenia treated with clozapine or olanzapine Mier, Daniela Schirmbeck, Frederike Stoessel, Gabriela Esslinger, Christine Rausch, Franziska Englisch, Susanne Eisenacher, Sarah de Haan, Lieuwe Meyer-Lindenberg, Andreas Kirsch, Peter Zink, Mathias Eur Arch Psychiatry Clin Neurosci Original Paper Obsessive–compulsive symptoms (OCS) in patients with schizophrenia are a common co-occurring condition, often associated with additional impairments. A subgroup of these patients develops OCS during treatment with second-generation antipsychotics (SGAs), most importantly clozapine and olanzapine. So far, little is known about possible neural mechanism of these SGAs, which seem to aggravate or induce OCS. To investigate the role of SGA treatment on neural activation and connectivity during emotional processing, patients were stratified according to their monotherapy into two groups (group I: clozapine or olanzapine, n = 20; group II: amisulpride or aripiprazole, n = 20). We used an fMRI approach, applying an implicit emotion recognition task. Group comparisons showed significantly higher frequency and severity of comorbid OCS in group I than group II. Task specific activation was attenuated in group I in the left amygdala. Furthermore, functional connectivity from left amygdala to right ventral striatum was reduced in group I. Reduced amygdala activation was associated with OCS severity. Recent literature suggests an involvement of an amygdala–cortico–striatal network in the pathogenesis of obsessive–compulsive disorder. The observed differential activation and connectivity pattern of the amygdala might thus indicate a neural mechanism for the development of SGA-associated OCS in patients with schizophrenia. Further neurobiological research and interventional studies are needed for causal inferences. Springer Berlin Heidelberg 2018-12-11 2019 /pmc/articles/PMC6841919/ /pubmed/30539230 http://dx.doi.org/10.1007/s00406-018-0965-4 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Paper
Mier, Daniela
Schirmbeck, Frederike
Stoessel, Gabriela
Esslinger, Christine
Rausch, Franziska
Englisch, Susanne
Eisenacher, Sarah
de Haan, Lieuwe
Meyer-Lindenberg, Andreas
Kirsch, Peter
Zink, Mathias
Reduced activity and connectivity of left amygdala in patients with schizophrenia treated with clozapine or olanzapine
title Reduced activity and connectivity of left amygdala in patients with schizophrenia treated with clozapine or olanzapine
title_full Reduced activity and connectivity of left amygdala in patients with schizophrenia treated with clozapine or olanzapine
title_fullStr Reduced activity and connectivity of left amygdala in patients with schizophrenia treated with clozapine or olanzapine
title_full_unstemmed Reduced activity and connectivity of left amygdala in patients with schizophrenia treated with clozapine or olanzapine
title_short Reduced activity and connectivity of left amygdala in patients with schizophrenia treated with clozapine or olanzapine
title_sort reduced activity and connectivity of left amygdala in patients with schizophrenia treated with clozapine or olanzapine
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6841919/
https://www.ncbi.nlm.nih.gov/pubmed/30539230
http://dx.doi.org/10.1007/s00406-018-0965-4
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