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Novel Gd(3+)-doped silica-based optical fiber material for dosimetry in proton therapy

Optical fibers hold promise for accurate dosimetry in small field proton therapy due to their superior spatial resolution and the lack of significant Cerenkov contamination in proton beams. One known drawback for most scintillation detectors is signal quenching in areas of high linear energy transfe...

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Autores principales: Hoehr, C., Morana, A., Duhamel, O., Capoen, B., Trinczek, M., Paillet, P., Duzenli, C., Bouazaoui, M., Bouwmans, G., Cassez, A., Ouerdane, Y., Boukenter, A., El Hamzaoui, H., Girard, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6841944/
https://www.ncbi.nlm.nih.gov/pubmed/31704964
http://dx.doi.org/10.1038/s41598-019-52608-5
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author Hoehr, C.
Morana, A.
Duhamel, O.
Capoen, B.
Trinczek, M.
Paillet, P.
Duzenli, C.
Bouazaoui, M.
Bouwmans, G.
Cassez, A.
Ouerdane, Y.
Boukenter, A.
El Hamzaoui, H.
Girard, S.
author_facet Hoehr, C.
Morana, A.
Duhamel, O.
Capoen, B.
Trinczek, M.
Paillet, P.
Duzenli, C.
Bouazaoui, M.
Bouwmans, G.
Cassez, A.
Ouerdane, Y.
Boukenter, A.
El Hamzaoui, H.
Girard, S.
author_sort Hoehr, C.
collection PubMed
description Optical fibers hold promise for accurate dosimetry in small field proton therapy due to their superior spatial resolution and the lack of significant Cerenkov contamination in proton beams. One known drawback for most scintillation detectors is signal quenching in areas of high linear energy transfer, as is the case in the Bragg peak region of a proton beam. In this study, we investigated the potential of innovative optical fiber bulk materials using the sol-gel technique for dosimetry in proton therapy. This type of glass is made of amorphous silica (SiO[Formula: see text] ) and is doped with Gd[Formula: see text] ions and possesses very interesting light emission properties with a luminescence band around 314 nm when exposed to protons. The fibers were manufactured at the University of Lille and tested at the TRIUMF Proton Therapy facility with 8.2–62.9 MeV protons and 2–6 nA of extracted beam current. Dose-rate dependence and quenching were measured and compared to other silica-based fibers also made by sol-gel techniques and doped with Ce[Formula: see text] and Cu[Formula: see text] . The three fibers present strong luminescence in the UV (Gd) or visible (Cu,Ce) under irradiation, with the emission intensities related directly to the proton flux. In addition, the 0.5 mm diameter Gd[Formula: see text] -doped fiber shows superior resolution of the Bragg peak, indicating significantly reduced quenching in comparison to the Ce[Formula: see text] and Cu[Formula: see text] fibers with a Birks’ constant, k[Formula: see text] , of (0.0162 [Formula: see text] 0.0003) cm/MeV in comparison to (0.0333 [Formula: see text] 0.0006) cm/MeV and (0.0352 [Formula: see text] 0.0003) cm/MeV, respectively. To our knowledge, this is the first report of such an interesting k[Formula: see text] for a silica-based optical fiber material, showing clearly that this fiber presents lower quenching than common plastic scintillators. This result demonstrates the high potential of this inorganic fiber material for proton therapy dosimetry.
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spelling pubmed-68419442019-11-14 Novel Gd(3+)-doped silica-based optical fiber material for dosimetry in proton therapy Hoehr, C. Morana, A. Duhamel, O. Capoen, B. Trinczek, M. Paillet, P. Duzenli, C. Bouazaoui, M. Bouwmans, G. Cassez, A. Ouerdane, Y. Boukenter, A. El Hamzaoui, H. Girard, S. Sci Rep Article Optical fibers hold promise for accurate dosimetry in small field proton therapy due to their superior spatial resolution and the lack of significant Cerenkov contamination in proton beams. One known drawback for most scintillation detectors is signal quenching in areas of high linear energy transfer, as is the case in the Bragg peak region of a proton beam. In this study, we investigated the potential of innovative optical fiber bulk materials using the sol-gel technique for dosimetry in proton therapy. This type of glass is made of amorphous silica (SiO[Formula: see text] ) and is doped with Gd[Formula: see text] ions and possesses very interesting light emission properties with a luminescence band around 314 nm when exposed to protons. The fibers were manufactured at the University of Lille and tested at the TRIUMF Proton Therapy facility with 8.2–62.9 MeV protons and 2–6 nA of extracted beam current. Dose-rate dependence and quenching were measured and compared to other silica-based fibers also made by sol-gel techniques and doped with Ce[Formula: see text] and Cu[Formula: see text] . The three fibers present strong luminescence in the UV (Gd) or visible (Cu,Ce) under irradiation, with the emission intensities related directly to the proton flux. In addition, the 0.5 mm diameter Gd[Formula: see text] -doped fiber shows superior resolution of the Bragg peak, indicating significantly reduced quenching in comparison to the Ce[Formula: see text] and Cu[Formula: see text] fibers with a Birks’ constant, k[Formula: see text] , of (0.0162 [Formula: see text] 0.0003) cm/MeV in comparison to (0.0333 [Formula: see text] 0.0006) cm/MeV and (0.0352 [Formula: see text] 0.0003) cm/MeV, respectively. To our knowledge, this is the first report of such an interesting k[Formula: see text] for a silica-based optical fiber material, showing clearly that this fiber presents lower quenching than common plastic scintillators. This result demonstrates the high potential of this inorganic fiber material for proton therapy dosimetry. Nature Publishing Group UK 2019-11-08 /pmc/articles/PMC6841944/ /pubmed/31704964 http://dx.doi.org/10.1038/s41598-019-52608-5 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Hoehr, C.
Morana, A.
Duhamel, O.
Capoen, B.
Trinczek, M.
Paillet, P.
Duzenli, C.
Bouazaoui, M.
Bouwmans, G.
Cassez, A.
Ouerdane, Y.
Boukenter, A.
El Hamzaoui, H.
Girard, S.
Novel Gd(3+)-doped silica-based optical fiber material for dosimetry in proton therapy
title Novel Gd(3+)-doped silica-based optical fiber material for dosimetry in proton therapy
title_full Novel Gd(3+)-doped silica-based optical fiber material for dosimetry in proton therapy
title_fullStr Novel Gd(3+)-doped silica-based optical fiber material for dosimetry in proton therapy
title_full_unstemmed Novel Gd(3+)-doped silica-based optical fiber material for dosimetry in proton therapy
title_short Novel Gd(3+)-doped silica-based optical fiber material for dosimetry in proton therapy
title_sort novel gd(3+)-doped silica-based optical fiber material for dosimetry in proton therapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6841944/
https://www.ncbi.nlm.nih.gov/pubmed/31704964
http://dx.doi.org/10.1038/s41598-019-52608-5
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