Cargando…

Glial cell line-derived neurotrophic factor (GDNF) mediates hepatic stellate cell activation via ALK5/Smad signalling

OBJECTIVE: Although glial cell line-derived neurotrophic factor (GDNF) is a member of the transforming growth factor-β superfamily, its function in liver fibrosis has rarely been studied. Here, we investigated the role of GDNF in hepatic stellate cell (HSC) activation and liver fibrosis in humans an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tao, Le, Ma, Wenting, Wu, Liu, Xu, Mingyi, Yang, Yanqin, Zhang, Wei, Sha, Wenjun, Li, Hongshan, Xu, Jianrong, Feng, Rilu, Xue, Dongying, Zhang, Jie, Dooley, Steven, Seki, Ekihiro, Liu, Ping, Liu, Cheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2019
Materias:	Hepatology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842044/ https://www.ncbi.nlm.nih.gov/pubmed/31171625 http://dx.doi.org/10.1136/gutjnl-2018-317872

Ejemplares similares

Serum Glial Cell Line-Derived Neurotrophic Factor (sGDNF) Is a Novel Biomarker in Predicting Cirrhosis in Patients with Chronic Hepatitis B
por: Yang, Guangyue, et al.
Publicado: (2022)

Fluorofenidone alleviates liver fibrosis by inhibiting hepatic stellate cell autophagy via the TGF-β1/Smad pathway: implications for liver cancer
por: Peng, Xiongqun, et al.
Publicado: (2023)

History of Glial Cell Line-Derived Neurotrophic Factor (GDNF) and Its Use for Spinal Cord Injury Repair
por: Walker, Melissa J., et al.
Publicado: (2018)

Axon Guidance of Sympathetic Neurons to Cardiomyocytes by Glial Cell Line-Derived Neurotrophic Factor (GDNF)
por: Miwa, Keiko, et al.
Publicado: (2013)

Glial Cell Line-Derived Neurotrophic Factor (GDNF) as a Novel Candidate Gene of Anxiety
por: Kotyuk, Eszter, et al.
Publicado: (2013)

CD248/endosialin critically regulates hepatic stellate cell proliferation during chronic liver injury via a PDGF-regulated mechanism
por: Wilhelm, Annika, et al.
Publicado: (2016)

Expression of Glial Cell Line-Derived Neurotrophic Factor (GDNF) and the GDNF Family Receptor Alpha Subunit 1 in the Paravaginal Ganglia of Nulliparous and Primiparous Rabbits
por: García-Villamar, Verónica, et al.
Publicado: (2018)

The RET–Glial Cell-derived Neurotrophic Factor (GDNF) Pathway Stimulates Migration and Chemoattraction of Epithelial Cells
por: Tang, Ming-Jer, et al.
Publicado: (1998)

MicroRNA regulation of central glial cell line-derived neurotrophic factor (GDNF) signalling in depression
por: Maheu, M, et al.
Publicado: (2015)

The central glial cell line-derived neurotrophic factor (GDNF) regulates pulmonary function in asthmatic rats
por: Wang, Xiaoyan, et al.
Publicado: (2023)

Serum glial cell line-derived neurotrophic factor (GDNF) a potential biomarker of executive function in Parkinson’s disease
por: Tong, Shu-Yan, et al.
Publicado: (2023)

The Role of Nerve Growth Factor (NGF) and Glial Cell Line-Derived Neurotrophic Factor (GDNF) in Tic Disorders
por: Karayagmurlu, Ali, et al.
Publicado: (2018)

The Actin Cytoskeleton Is Involved in Glial Cell Line-Derived Neurotrophic Factor (GDNF)-Induced Ret Translocation into Lipid Rafts in Dopaminergic Neuronal Cells
por: Li, Li, et al.
Publicado: (2017)

Neuroimmunomodulation of adrenoblockers during liver cirrhosis: modulation of hepatic stellate cell activity
por: Medina Pizaño, Mariana Yazmin, et al.
Publicado: (2023)

Glial Cell Line-Derived Neurotrophic Factor (GDNF) Promotes Angiogenesis through the Demethylation of the Fibromodulin (FMOD) Promoter in Glioblastoma
por: Chen, Maohua, et al.
Publicado: (2018)

Glial cell line-derived neurotrophic factor (GDNF) in patients with primary open-angle glaucoma and age-related cataract
por: Shpak, Alexander A., et al.
Publicado: (2022)

Brain derived neurotrophic factor declines after complete curative resection in gastrointestinal cancer
por: Guzel, Tomasz, et al.
Publicado: (2021)

Evaluation of an AAV2-Based Rapamycin-Regulated Glial Cell Line-Derived Neurotrophic Factor (GDNF) Expression Vector System
por: Hadaczek, Piotr, et al.
Publicado: (2011)

The Niche-Derived Glial Cell Line-Derived Neurotrophic Factor (GDNF) Induces Migration of Mouse Spermatogonial Stem/Progenitor Cells
por: Dovere, Lisa, et al.
Publicado: (2013)

Testosterone upregulates glial cell line-derived neurotrophic factor (GDNF) and promotes neuroinflammation to enhance glioma cell survival and proliferation
por: Kanwore, Kouminin, et al.
Publicado: (2023)

Combined effect of olfactory ensheathing cell (OEC) transplantation and glial cell line-derived neurotrophic factor (GDNF) intravitreal injection on optic nerve injury in rats
por: Liu, Yong, et al.
Publicado: (2010)

PD-L1 blockade liberates intrinsic antitumourigenic properties of glycolytic macrophages in hepatocellular carcinoma
por: Lu, Li-Gong, et al.
Publicado: (2022)

Glial cell line-derived neurotrophic factor (GDNF) attenuates the peripheral neuromuscular dysfunction without inhibiting the activation of spinal microglia/monocyte
por: Xie, Fei, et al.
Publicado: (2018)

Efficacy and safety of hyperbaric oxygen therapy for moderate-to-severe ulcerative colitis: a protocol for a systematic review and meta-analysis
por: Luo, Lihong, et al.
Publicado: (2021)

Gray matter volume reduction in orbitofrontal cortex correlated with plasma glial cell line-derived neurotrophic factor (GDNF) levels within major depressive disorder
por: Wu, Yifan, et al.
Publicado: (2023)

PBMC transcriptomics identifies immune-metabolism disorder during the development of HBV-ACLF
por: Li, Jiang, et al.
Publicado: (2022)

Mass cytometry-based peripheral blood analysis as a novel tool for early detection of solid tumours: a multicentre study
por: Zhang, Qi, et al.
Publicado: (2023)

MicroRNA-206 promotes the recruitment of CD8(+) T cells by driving M1 polarisation of Kupffer cells
por: Liu, Ningning, et al.
Publicado: (2022)

TGF-β2 silencing to target biliary-derived liver diseases
por: Dropmann, Anne, et al.
Publicado: (2020)

Melatonin promotes goat spermatogonia stem cells (SSCs) proliferation by stimulating glial cell line-derived neurotrophic factor (GDNF) production in Sertoli cells
por: Niu, Bowen, et al.
Publicado: (2016)

Comparable efficacy with entecavir monotherapy and tenofovir–entecavir combination in chronic hepatitis B patients
por: Baqai, Sumbella, et al.
Publicado: (2015)

Integrative metabolomic characterisation identifies altered portal vein serum metabolome contributing to human hepatocellular carcinoma
por: Liu, Jinkai, et al.
Publicado: (2022)

Intestinal Epithelial Barrier Maturation by Enteric Glial Cells Is GDNF-Dependent
por: Meir, Michael, et al.
Publicado: (2021)

Novel strategy for oral peptide delivery in incretin-based diabetes treatment
por: Xu, Yining, et al.
Publicado: (2020)

Changing trends of hospitalisation of liver cirrhosis in Beijing, China
por: Bao, Xiao-Yuan, et al.
Publicado: (2015)

Three-dimensional bioprinted hepatorganoids prolong survival of mice with liver failure
por: Yang, Huayu, et al.
Publicado: (2021)

Quasispecies characteristic in “a” determinant region is a potential predictor for the risk of immunoprophylaxis failure of mother-to-child-transmission of sub-genotype C2 hepatitis B virus: a prospective nested case–control study
por: Xiao, Yiwei, et al.
Publicado: (2020)

Engineered anti-PDL1 with IFNα targets both immunoinhibitory and activating signals in the liver to break HBV immune tolerance
por: Meng, Chao-Yang, et al.
Publicado: (2023)

High-affinity neoantigens correlate with better prognosis and trigger potent antihepatocellular carcinoma (HCC) activity by activating CD39(+)CD8(+) T cells
por: Liu, Ting, et al.
Publicado: (2021)

Genome-wide mapping of 5-hydroxymethylcytosines in circulating cell-free DNA as a non-invasive approach for early detection of hepatocellular carcinoma
por: Cai, Jiabin, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_4nq1j8jf013ovh700ff8vo97g7