Ikaros tumor suppressor function includes induction of active enhancers and super-enhancers along with pioneering activity

Ikaros encodes a transcription factor that functions as a tumor suppressor in T-cell acute lymphoblastic leukemia (T-ALL). The mechanisms through which Ikaros regulates gene expression and cellular proliferation in T-ALL are unknown. Re-introduction of Ikaros into Ikaros-null T-ALL cells resulted in...

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Detalles Bibliográficos
Autores principales: Ding, Yali, Zhang, Bo, Payne, Jonathon L., Song, Chunhua, Ge, Zheng, Gowda, Chandrika, Iyer, Soumya, Dhanyamraju, Pavan K., Dorsam, Glenn, Reeves, Mark E., Desai, Dhimant, Huang, Suming, Payne, Kimberly J., Yue, Feng, Dovat, Sinisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842075/
https://www.ncbi.nlm.nih.gov/pubmed/31073152
http://dx.doi.org/10.1038/s41375-019-0474-0

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