Cooperation of Dnmt3a R878H with Nras G12D promotes leukemogenesis in knock-in mice: a pilot study

BACKGROUND: DNMT3A R882H, a frequent mutation in acute myeloid leukemia (AML), plays a critical role in malignant hematopoiesis. Recent findings suggest that DNMT3A mutant acts as a founder mutation and requires additional genetic events to induce full-blown AML. Here, we investigated the cooperatio...

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Detalles Bibliográficos
Autores principales: Shi, Xiaodong, Yang, Ying, Shang, Siqi, Wu, Songfang, Zhang, Weina, Peng, Lijun, Huang, Ting, Zhang, Ruihong, Ren, Ruibao, Mi, Jianqing, Wang, Yueying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842226/
https://www.ncbi.nlm.nih.gov/pubmed/31703632
http://dx.doi.org/10.1186/s12885-019-6207-y

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