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Reduced sphingolipid hydrolase activities, substrate accumulation and ganglioside decline in Parkinson’s disease
BACKGROUND: Haploinsufficiency in the Gaucher disease GBA gene, which encodes the lysosomal glucocerebrosidase GBA, and ageing represent major risk factors for developing Parkinson’s disease (PD). Recently, more than fifty other lysosomal storage disorder gene variants have been identified in PD, im...
Autores principales: | Huebecker, Mylene, Moloney, Elizabeth B., van der Spoel, Aarnoud C., Priestman, David A., Isacson, Ole, Hallett, Penelope J., Platt, Frances M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842240/ https://www.ncbi.nlm.nih.gov/pubmed/31703585 http://dx.doi.org/10.1186/s13024-019-0339-z |
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