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Enhancing Base Excision Repair of Mitochondrial DNA to Reduce Ischemic Injury Following Reperfusion

We hypothesize that enhancing mitochondrial base excision repair (BER) capability in brain will reduce reperfusion-associated ischemic brain injury. Post-stroke reperfusion was modeled in mice via transient filament occlusion of the middle cerebral artery (60 min) (transient MCAO). Administration of...

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Detalles Bibliográficos
Autores principales:	Simon, Roger, Meller, Robert, Yang, Tao, Pearson, Andrea, Wilson, Glenn
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2018
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842339/ https://www.ncbi.nlm.nih.gov/pubmed/30535792 http://dx.doi.org/10.1007/s12975-018-0680-5

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