Hospital mortality in acute coronary syndrome: adjustment of GRACE score by D-dimer enables a more accurate prediction in a prospective cohort study

BACKGROUD: To assess the value of D-dimer and its combination with The Global Registry of Acute Coronary Events (GRACE) score in predicting in-hospital mortality in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI). METHODS: In 5923 ACS patients undergoi...

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Autores principales: Yu, Tongtong, Jiao, Yundi, Song, Jia, He, Dongxu, Wu, Jiake, Sun, Zhijun, Sun, Zhaoqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842504/
https://www.ncbi.nlm.nih.gov/pubmed/31707974
http://dx.doi.org/10.1186/s12872-019-1239-4
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author Yu, Tongtong
Jiao, Yundi
Song, Jia
He, Dongxu
Wu, Jiake
Sun, Zhijun
Sun, Zhaoqing
author_facet Yu, Tongtong
Jiao, Yundi
Song, Jia
He, Dongxu
Wu, Jiake
Sun, Zhijun
Sun, Zhaoqing
author_sort Yu, Tongtong
collection PubMed
description BACKGROUD: To assess the value of D-dimer and its combination with The Global Registry of Acute Coronary Events (GRACE) score in predicting in-hospital mortality in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI). METHODS: In 5923 ACS patients undergoing PCI, the role of D-dimer and the added value of D-dimer to GRACE score for predicting in-hospital mortality were tested. RESULTS: After multivariable adjustment, D-dimer could significantly predict in-hospital mortality. Also, it could significantly improve the prognostic performance of GRACE score (C-statistic: z = 2.269, p = 0.023; IDI: 0.016, p = 0.032; NRI: 0.291, p = 0.035). CONCLUSION: In patients with ACS undergoing PCI, D-dimer was an independent predictor of in-hospital death. It could also improve the prognostic performance of GRACE score.
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spelling pubmed-68425042019-11-14 Hospital mortality in acute coronary syndrome: adjustment of GRACE score by D-dimer enables a more accurate prediction in a prospective cohort study Yu, Tongtong Jiao, Yundi Song, Jia He, Dongxu Wu, Jiake Sun, Zhijun Sun, Zhaoqing BMC Cardiovasc Disord Research Article BACKGROUD: To assess the value of D-dimer and its combination with The Global Registry of Acute Coronary Events (GRACE) score in predicting in-hospital mortality in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI). METHODS: In 5923 ACS patients undergoing PCI, the role of D-dimer and the added value of D-dimer to GRACE score for predicting in-hospital mortality were tested. RESULTS: After multivariable adjustment, D-dimer could significantly predict in-hospital mortality. Also, it could significantly improve the prognostic performance of GRACE score (C-statistic: z = 2.269, p = 0.023; IDI: 0.016, p = 0.032; NRI: 0.291, p = 0.035). CONCLUSION: In patients with ACS undergoing PCI, D-dimer was an independent predictor of in-hospital death. It could also improve the prognostic performance of GRACE score. BioMed Central 2019-11-10 /pmc/articles/PMC6842504/ /pubmed/31707974 http://dx.doi.org/10.1186/s12872-019-1239-4 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Yu, Tongtong
Jiao, Yundi
Song, Jia
He, Dongxu
Wu, Jiake
Sun, Zhijun
Sun, Zhaoqing
Hospital mortality in acute coronary syndrome: adjustment of GRACE score by D-dimer enables a more accurate prediction in a prospective cohort study
title Hospital mortality in acute coronary syndrome: adjustment of GRACE score by D-dimer enables a more accurate prediction in a prospective cohort study
title_full Hospital mortality in acute coronary syndrome: adjustment of GRACE score by D-dimer enables a more accurate prediction in a prospective cohort study
title_fullStr Hospital mortality in acute coronary syndrome: adjustment of GRACE score by D-dimer enables a more accurate prediction in a prospective cohort study
title_full_unstemmed Hospital mortality in acute coronary syndrome: adjustment of GRACE score by D-dimer enables a more accurate prediction in a prospective cohort study
title_short Hospital mortality in acute coronary syndrome: adjustment of GRACE score by D-dimer enables a more accurate prediction in a prospective cohort study
title_sort hospital mortality in acute coronary syndrome: adjustment of grace score by d-dimer enables a more accurate prediction in a prospective cohort study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842504/
https://www.ncbi.nlm.nih.gov/pubmed/31707974
http://dx.doi.org/10.1186/s12872-019-1239-4
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