The level of activity of the alternative lengthening of telomeres correlates with patient age in IDH-mutant ATRX-loss-of-expression anaplastic astrocytomas

All cancer cells need to maintain functional telomeres to sustain continuous cell division and proliferation. In human diffuse gliomas, functional telomeres are maintained due either to reactivation of telomerase expression, the main pathway in most cancer types, or to activation of a mechanism call...

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Detalles Bibliográficos
Autores principales: Grandin, Nathalie, Pereira, Bruno, Cohen, Camille, Billard, Pauline, Dehais, Caroline, Carpentier, Catherine, Idbaih, Ahmed, Bielle, Franck, Ducray, François, Figarella-Branger, Dominique, Delattre, Jean-Yves, Sanson, Marc, Lomonte, Patrick, Poncet, Delphine, Verrelle, Pierre, Charbonneau, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842523/
https://www.ncbi.nlm.nih.gov/pubmed/31706351
http://dx.doi.org/10.1186/s40478-019-0833-0

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