Mice expressing the variant rs1143679 allele of ITGAM (CD11b) show impaired DC-mediated T cell proliferation

Genome-wide association studies (GWAS) and functional genomic analyses have implicated several ITGAM (CD11b) single-nucleotide polymorphisms (SNPs) in the development of SLE and other disorders. ITGAM encodes the α(M) chain of the β(2) integrin Mac-1, a receptor that plays important roles in myeloid...

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Detalles Bibliográficos
Autores principales: Avery, Justin T., Jimenez, Rachel V., Blake, Joseph L., Wright, Tyler T., Leόn-Ruiz, Beatriz, Schoeb, Trenton R., Szalai, Alexander J., Bullard, Daniel C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842653/
https://www.ncbi.nlm.nih.gov/pubmed/31673770
http://dx.doi.org/10.1007/s00335-019-09819-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842653/
https://www.ncbi.nlm.nih.gov/pubmed/31673770
http://dx.doi.org/10.1007/s00335-019-09819-y

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