Hairless-knockout piglets generated using the clustered regularly interspaced short palindromic repeat/CRISPR-associated-9 exhibit abnormalities in the skin and thymus

The nuclear receptor corepressor Hairless (HR) interacts with nuclear receptors and controls expression of specific target genes involved in hair morphogenesis and hair follicle cycling. Patients with HR gene mutations exhibit atrichia, and in rare cases, immunodeficiency. Pigs with HR gene mutation...

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Detalles Bibliográficos
Autores principales: Gao, Qing-Shan, Xuan, Mei-Fu, Luo, Zhao-Bo, Paek, Hyo-Jin, Kang, Jin-Dan, Yin, Xi-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Association for Laboratory Animal Science 2019
Materias:
Original
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842791/
https://www.ncbi.nlm.nih.gov/pubmed/31308290
http://dx.doi.org/10.1538/expanim.19-0018

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