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Maturation of Gut Microbiota and Circulating Regulatory T Cells and Development of IgE Sensitization in Early Life

Recent studies suggest that the cross-talk between the gut microbiota and human immune system during the first year of life is an important regulator of the later development of atopic diseases. We explored the changes in the gut microbiota, blood regulatory T cells, and atopic sensitization in a bi...

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Autores principales: Ruohtula, Terhi, de Goffau, Marcus C., Nieminen, Janne K., Honkanen, Jarno, Siljander, Heli, Hämäläinen, Anu-Maaria, Peet, Aleksandr, Tillmann, Vallo, Ilonen, Jorma, Niemelä, Onni, Welling, Gjalt W., Knip, Mikael, Harmsen, Hermie J., Vaarala, Outi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842923/
https://www.ncbi.nlm.nih.gov/pubmed/31749800
http://dx.doi.org/10.3389/fimmu.2019.02494
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author Ruohtula, Terhi
de Goffau, Marcus C.
Nieminen, Janne K.
Honkanen, Jarno
Siljander, Heli
Hämäläinen, Anu-Maaria
Peet, Aleksandr
Tillmann, Vallo
Ilonen, Jorma
Niemelä, Onni
Welling, Gjalt W.
Knip, Mikael
Harmsen, Hermie J.
Vaarala, Outi
author_facet Ruohtula, Terhi
de Goffau, Marcus C.
Nieminen, Janne K.
Honkanen, Jarno
Siljander, Heli
Hämäläinen, Anu-Maaria
Peet, Aleksandr
Tillmann, Vallo
Ilonen, Jorma
Niemelä, Onni
Welling, Gjalt W.
Knip, Mikael
Harmsen, Hermie J.
Vaarala, Outi
author_sort Ruohtula, Terhi
collection PubMed
description Recent studies suggest that the cross-talk between the gut microbiota and human immune system during the first year of life is an important regulator of the later development of atopic diseases. We explored the changes in the gut microbiota, blood regulatory T cells, and atopic sensitization in a birth-cohort of Estonian and Finnish children followed from 3 to 36 months of age. We describe here an infant Treg phenotype characterized by high Treg frequency, the maturation of Treg population characterized by a decrease in their frequency accompanied with an increase in the highly activated Treg cells. These changes in Treg population associated first with the relative abundance of Bifidobacterium longum followed by increasing colonization with butyrate producing bacteria. High bifidobacterial abundance in the neonatal microbiota appeared to be protective, while colonization with Bacteroides and E. coli was associated with later risk of allergy. Estonian children with lower risk of IgE mediated allergic diseases than Finnish children showed an earlier maturation of the gut microbiota, detected as earlier switch to an increasing abundance of butyrate-producing bacteria, combined with an earlier maturation of Treg cell phenotype and total IgE production. The children with established allergic diseases by age 3 showed a decreased abundance of butyrate producing Faecalibacterium. These results suggest that as well as the maintenance of a bifidobacterial dominated gut microbiota is important during the first weeks of life, the overtake by butyrate producing bacteria seems to be a beneficial shift, which should not be postponed.
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spelling pubmed-68429232019-11-20 Maturation of Gut Microbiota and Circulating Regulatory T Cells and Development of IgE Sensitization in Early Life Ruohtula, Terhi de Goffau, Marcus C. Nieminen, Janne K. Honkanen, Jarno Siljander, Heli Hämäläinen, Anu-Maaria Peet, Aleksandr Tillmann, Vallo Ilonen, Jorma Niemelä, Onni Welling, Gjalt W. Knip, Mikael Harmsen, Hermie J. Vaarala, Outi Front Immunol Immunology Recent studies suggest that the cross-talk between the gut microbiota and human immune system during the first year of life is an important regulator of the later development of atopic diseases. We explored the changes in the gut microbiota, blood regulatory T cells, and atopic sensitization in a birth-cohort of Estonian and Finnish children followed from 3 to 36 months of age. We describe here an infant Treg phenotype characterized by high Treg frequency, the maturation of Treg population characterized by a decrease in their frequency accompanied with an increase in the highly activated Treg cells. These changes in Treg population associated first with the relative abundance of Bifidobacterium longum followed by increasing colonization with butyrate producing bacteria. High bifidobacterial abundance in the neonatal microbiota appeared to be protective, while colonization with Bacteroides and E. coli was associated with later risk of allergy. Estonian children with lower risk of IgE mediated allergic diseases than Finnish children showed an earlier maturation of the gut microbiota, detected as earlier switch to an increasing abundance of butyrate-producing bacteria, combined with an earlier maturation of Treg cell phenotype and total IgE production. The children with established allergic diseases by age 3 showed a decreased abundance of butyrate producing Faecalibacterium. These results suggest that as well as the maintenance of a bifidobacterial dominated gut microbiota is important during the first weeks of life, the overtake by butyrate producing bacteria seems to be a beneficial shift, which should not be postponed. Frontiers Media S.A. 2019-10-23 /pmc/articles/PMC6842923/ /pubmed/31749800 http://dx.doi.org/10.3389/fimmu.2019.02494 Text en Copyright © 2019 Ruohtula, de Goffau, Nieminen, Honkanen, Siljander, Hämäläinen, Peet, Tillmann, Ilonen, Niemelä, Welling, Knip, Harmsen and Vaarala. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Ruohtula, Terhi
de Goffau, Marcus C.
Nieminen, Janne K.
Honkanen, Jarno
Siljander, Heli
Hämäläinen, Anu-Maaria
Peet, Aleksandr
Tillmann, Vallo
Ilonen, Jorma
Niemelä, Onni
Welling, Gjalt W.
Knip, Mikael
Harmsen, Hermie J.
Vaarala, Outi
Maturation of Gut Microbiota and Circulating Regulatory T Cells and Development of IgE Sensitization in Early Life
title Maturation of Gut Microbiota and Circulating Regulatory T Cells and Development of IgE Sensitization in Early Life
title_full Maturation of Gut Microbiota and Circulating Regulatory T Cells and Development of IgE Sensitization in Early Life
title_fullStr Maturation of Gut Microbiota and Circulating Regulatory T Cells and Development of IgE Sensitization in Early Life
title_full_unstemmed Maturation of Gut Microbiota and Circulating Regulatory T Cells and Development of IgE Sensitization in Early Life
title_short Maturation of Gut Microbiota and Circulating Regulatory T Cells and Development of IgE Sensitization in Early Life
title_sort maturation of gut microbiota and circulating regulatory t cells and development of ige sensitization in early life
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842923/
https://www.ncbi.nlm.nih.gov/pubmed/31749800
http://dx.doi.org/10.3389/fimmu.2019.02494
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