The NF-κB RelA Transcription Factor Is Critical for Regulatory T Cell Activation and Stability

Regulatory T cells (Tregs) play a major role in immune homeostasis and in the prevention of autoimmune diseases. It has been shown that c-Rel is critical in Treg thymic differentiation, but little is known on the role of NF-κB on mature Treg biology. We thus generated mice with a specific knockout o...

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Detalles Bibliográficos
Autores principales: Ronin, Emilie, Lubrano di Ricco, Martina, Vallion, Romain, Divoux, Jordane, Kwon, Ho-Keun, Grégoire, Sylvie, Collares, Davi, Rouers, Angéline, Baud, Véronique, Benoist, Christophe, Salomon, Benoit L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842949/
https://www.ncbi.nlm.nih.gov/pubmed/31749798
http://dx.doi.org/10.3389/fimmu.2019.02487

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