Nuclear Tau, p53 and Pin1 Regulate PARN-Mediated Deadenylation and Gene Expression

While nuclear tau plays a role in DNA damage response (DDR) and chromosome relaxation, the mechanisms behind these functions are not fully understood. Here, we show that tau forms complex(es) with factors involved in nuclear mRNA processing such as tumor suppressor p53 and poly(A)-specific ribonucle...

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Detalles Bibliográficos
Autores principales: Baquero, Jorge, Varriano, Sophia, Ordonez, Martha, Kuczaj, Pawel, Murphy, Michael R., Aruggoda, Gamage, Lundine, Devon, Morozova, Viktoriya, Makki, Ali Elhadi, Alonso, Alejandra del C., Kleiman, Frida E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6843027/
https://www.ncbi.nlm.nih.gov/pubmed/31749682
http://dx.doi.org/10.3389/fnmol.2019.00242

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