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A Review on the Assessment of Radiation Induced Salivary Gland Damage After Radiotherapy

Head and neck cancers are common in Southern China including Hong Kong. Intensity modulated radiotherapy has been the treatment of choice for these patients. Although radiotherapy provides good local control, radiotherapy treatment side-effects are still inevitable due to close proximity of the orga...

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Autores principales: Wu, Vincent W. C., Leung, Kit Yee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6843028/
https://www.ncbi.nlm.nih.gov/pubmed/31750235
http://dx.doi.org/10.3389/fonc.2019.01090
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author Wu, Vincent W. C.
Leung, Kit Yee
author_facet Wu, Vincent W. C.
Leung, Kit Yee
author_sort Wu, Vincent W. C.
collection PubMed
description Head and neck cancers are common in Southern China including Hong Kong. Intensity modulated radiotherapy has been the treatment of choice for these patients. Although radiotherapy provides good local control, radiotherapy treatment side-effects are still inevitable due to close proximity of the organs at risk from the target volume. Xerostomia, which is caused due to the damage of salivary glands, is one of the main radiation induced toxicities in post-radiotherapy head and neck patients. This review article discusses the methods for the assessing of radiation induced salivary gland changes including the gland morphology and saliva flow rate. The discussion also includes the recovery of the salivary gland after radiotherapy and how it is affected by the dose. It is expected that the future direction in monitoring the recovery of salivary glands will focus in cellular or molecular levels, and the development of imaging biomarker.
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spelling pubmed-68430282019-11-20 A Review on the Assessment of Radiation Induced Salivary Gland Damage After Radiotherapy Wu, Vincent W. C. Leung, Kit Yee Front Oncol Oncology Head and neck cancers are common in Southern China including Hong Kong. Intensity modulated radiotherapy has been the treatment of choice for these patients. Although radiotherapy provides good local control, radiotherapy treatment side-effects are still inevitable due to close proximity of the organs at risk from the target volume. Xerostomia, which is caused due to the damage of salivary glands, is one of the main radiation induced toxicities in post-radiotherapy head and neck patients. This review article discusses the methods for the assessing of radiation induced salivary gland changes including the gland morphology and saliva flow rate. The discussion also includes the recovery of the salivary gland after radiotherapy and how it is affected by the dose. It is expected that the future direction in monitoring the recovery of salivary glands will focus in cellular or molecular levels, and the development of imaging biomarker. Frontiers Media S.A. 2019-10-17 /pmc/articles/PMC6843028/ /pubmed/31750235 http://dx.doi.org/10.3389/fonc.2019.01090 Text en Copyright © 2019 Wu and Leung. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Wu, Vincent W. C.
Leung, Kit Yee
A Review on the Assessment of Radiation Induced Salivary Gland Damage After Radiotherapy
title A Review on the Assessment of Radiation Induced Salivary Gland Damage After Radiotherapy
title_full A Review on the Assessment of Radiation Induced Salivary Gland Damage After Radiotherapy
title_fullStr A Review on the Assessment of Radiation Induced Salivary Gland Damage After Radiotherapy
title_full_unstemmed A Review on the Assessment of Radiation Induced Salivary Gland Damage After Radiotherapy
title_short A Review on the Assessment of Radiation Induced Salivary Gland Damage After Radiotherapy
title_sort review on the assessment of radiation induced salivary gland damage after radiotherapy
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6843028/
https://www.ncbi.nlm.nih.gov/pubmed/31750235
http://dx.doi.org/10.3389/fonc.2019.01090
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