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Does Colchicine Substitute Corticosteroids in Treatment of Idiopathic and Viral Pediatric Pericarditis?

Background and Objectives: Recurrence of pericarditis (ROP) is an important complication of the acute pericarditis. The aim of this study was to analyse the influence of aetiology, clinical findings and treatment on the outcome of acute pericarditis. Methods: Data were retrospectively collected from...

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Autores principales: Vukomanovic, Vladislav, Prijic, Sergej, Krasic, Stasa, Borovic, Ruzica, Ninic, Sanja, Nesic, Dejan, Bjelakovic, Bojko, Popovic, Sasa, Stajević, Mila, Petrović, Gordana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6843123/
https://www.ncbi.nlm.nih.gov/pubmed/31547038
http://dx.doi.org/10.3390/medicina55100609
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author Vukomanovic, Vladislav
Prijic, Sergej
Krasic, Stasa
Borovic, Ruzica
Ninic, Sanja
Nesic, Dejan
Bjelakovic, Bojko
Popovic, Sasa
Stajević, Mila
Petrović, Gordana
author_facet Vukomanovic, Vladislav
Prijic, Sergej
Krasic, Stasa
Borovic, Ruzica
Ninic, Sanja
Nesic, Dejan
Bjelakovic, Bojko
Popovic, Sasa
Stajević, Mila
Petrović, Gordana
author_sort Vukomanovic, Vladislav
collection PubMed
description Background and Objectives: Recurrence of pericarditis (ROP) is an important complication of the acute pericarditis. The aim of this study was to analyse the influence of aetiology, clinical findings and treatment on the outcome of acute pericarditis. Methods: Data were retrospectively collected from medical records of patients treated from 2011 to 2019 at a tertiary referent heart paediatric center. Results: Our investigation included 56 children with idiopathic and viral pericarditis. Relapse was registered in 8/56 patients, 2/29 (7.41%) treated with nonsteroidal anti-inflammatory drugs (NSAID) and 6/27 (28.57%) treated with corticosteroids (CS) and NSAID. Independent risk factors for ROP were viral pericarditis (p = 0.01, OR 31.46), lack of myocardial affection (p = 0.03, OR 29.15), CS use (p = 0.02, OR 29.02) and ESR ≥ 50 mm/h (p = 0.03, OR 25.23). In 4/8 patients the first recurrence was treated with NSAID and colchicine, while treatment of 4/8 patients included CS. Children with ROP treated with CS had higher median number of recurrence (5, IQR: 2–15) than those treated with colchicine (0, IQR: 0–0.75). Conclusions: Independent risk factors for recurrence are CS treatment, viral aetiology, pericarditis only and ESR ≥ 50 mm/h. Acute pericarditis should be treated with NSAID. Colchicine and NSAID might be recommended in children with the first ROP.
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spelling pubmed-68431232019-11-25 Does Colchicine Substitute Corticosteroids in Treatment of Idiopathic and Viral Pediatric Pericarditis? Vukomanovic, Vladislav Prijic, Sergej Krasic, Stasa Borovic, Ruzica Ninic, Sanja Nesic, Dejan Bjelakovic, Bojko Popovic, Sasa Stajević, Mila Petrović, Gordana Medicina (Kaunas) Article Background and Objectives: Recurrence of pericarditis (ROP) is an important complication of the acute pericarditis. The aim of this study was to analyse the influence of aetiology, clinical findings and treatment on the outcome of acute pericarditis. Methods: Data were retrospectively collected from medical records of patients treated from 2011 to 2019 at a tertiary referent heart paediatric center. Results: Our investigation included 56 children with idiopathic and viral pericarditis. Relapse was registered in 8/56 patients, 2/29 (7.41%) treated with nonsteroidal anti-inflammatory drugs (NSAID) and 6/27 (28.57%) treated with corticosteroids (CS) and NSAID. Independent risk factors for ROP were viral pericarditis (p = 0.01, OR 31.46), lack of myocardial affection (p = 0.03, OR 29.15), CS use (p = 0.02, OR 29.02) and ESR ≥ 50 mm/h (p = 0.03, OR 25.23). In 4/8 patients the first recurrence was treated with NSAID and colchicine, while treatment of 4/8 patients included CS. Children with ROP treated with CS had higher median number of recurrence (5, IQR: 2–15) than those treated with colchicine (0, IQR: 0–0.75). Conclusions: Independent risk factors for recurrence are CS treatment, viral aetiology, pericarditis only and ESR ≥ 50 mm/h. Acute pericarditis should be treated with NSAID. Colchicine and NSAID might be recommended in children with the first ROP. MDPI 2019-09-20 /pmc/articles/PMC6843123/ /pubmed/31547038 http://dx.doi.org/10.3390/medicina55100609 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Vukomanovic, Vladislav
Prijic, Sergej
Krasic, Stasa
Borovic, Ruzica
Ninic, Sanja
Nesic, Dejan
Bjelakovic, Bojko
Popovic, Sasa
Stajević, Mila
Petrović, Gordana
Does Colchicine Substitute Corticosteroids in Treatment of Idiopathic and Viral Pediatric Pericarditis?
title Does Colchicine Substitute Corticosteroids in Treatment of Idiopathic and Viral Pediatric Pericarditis?
title_full Does Colchicine Substitute Corticosteroids in Treatment of Idiopathic and Viral Pediatric Pericarditis?
title_fullStr Does Colchicine Substitute Corticosteroids in Treatment of Idiopathic and Viral Pediatric Pericarditis?
title_full_unstemmed Does Colchicine Substitute Corticosteroids in Treatment of Idiopathic and Viral Pediatric Pericarditis?
title_short Does Colchicine Substitute Corticosteroids in Treatment of Idiopathic and Viral Pediatric Pericarditis?
title_sort does colchicine substitute corticosteroids in treatment of idiopathic and viral pediatric pericarditis?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6843123/
https://www.ncbi.nlm.nih.gov/pubmed/31547038
http://dx.doi.org/10.3390/medicina55100609
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