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Antibody Testing in Estimating Past Exposure to Chlamydia trachomatis in The Netherlands Chlamydia Cohort Study

The asymptomatic course of Chlamydia trachomatis (CT) infections can result in underestimated CT lifetime prevalence. Antibody testing might improve this estimate. We assessed CT antibody positivity and predictive factors thereof in the Netherlands Chlamydia Cohort Study. Women who had ≥1 CT Nucleic...

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Autores principales: Hoenderboom, Bernice M., van Willige, Michelle E., Land, Jolande A., Pleijster, Jolein, Götz, Hannelore M., van Bergen, Jan E. A. M., Dukers-Muijrers, Nicole H. T. M., Hoebe, Christian J. P. A., van Benthem, Birgit H. B., Morré, Servaas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6843155/
https://www.ncbi.nlm.nih.gov/pubmed/31614620
http://dx.doi.org/10.3390/microorganisms7100442
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author Hoenderboom, Bernice M.
van Willige, Michelle E.
Land, Jolande A.
Pleijster, Jolein
Götz, Hannelore M.
van Bergen, Jan E. A. M.
Dukers-Muijrers, Nicole H. T. M.
Hoebe, Christian J. P. A.
van Benthem, Birgit H. B.
Morré, Servaas A.
author_facet Hoenderboom, Bernice M.
van Willige, Michelle E.
Land, Jolande A.
Pleijster, Jolein
Götz, Hannelore M.
van Bergen, Jan E. A. M.
Dukers-Muijrers, Nicole H. T. M.
Hoebe, Christian J. P. A.
van Benthem, Birgit H. B.
Morré, Servaas A.
author_sort Hoenderboom, Bernice M.
collection PubMed
description The asymptomatic course of Chlamydia trachomatis (CT) infections can result in underestimated CT lifetime prevalence. Antibody testing might improve this estimate. We assessed CT antibody positivity and predictive factors thereof in the Netherlands Chlamydia Cohort Study. Women who had ≥1 CT Nucleic Acid Amplification Test (NAAT) in the study (2008–2011) and who provided self-reported information on NAATs were tested for CT major outer membrane protein specific IgG in serum (2016). CT antibody positivity was assessed and predictive factors were identified using multivariable logistic regressions, separately for CT-positive women (≥1 positive NAAT or ≥1 self-reported positive CT test) and CT-negative women (negative by study NAAT and self-report). Of the 3,613 women studied, 833 (23.1%) were CT -positive. Among the CT-negative women, 208 (7.5%, 95% CI 6.5–8.5) tested positive for CT antibodies. This increased CT lifetime prevalence with 5.8% (95% CI 5.0–6.5). Among women with a CT-positive history, 338 (40.6%, 95% CI 38.5–44.1) tested positive. Predictive factors for antibody positivity related to lower social economic status, sexual risk behavior, multiple infections, higher body mass index, and non-smoking. CT antibody testing significantly increased the lifetime prevalence. Combining NAAT outcomes, self-reported positive tests, and antibody testing reduced misclassification in CT prevalence estimates.
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spelling pubmed-68431552019-11-25 Antibody Testing in Estimating Past Exposure to Chlamydia trachomatis in The Netherlands Chlamydia Cohort Study Hoenderboom, Bernice M. van Willige, Michelle E. Land, Jolande A. Pleijster, Jolein Götz, Hannelore M. van Bergen, Jan E. A. M. Dukers-Muijrers, Nicole H. T. M. Hoebe, Christian J. P. A. van Benthem, Birgit H. B. Morré, Servaas A. Microorganisms Article The asymptomatic course of Chlamydia trachomatis (CT) infections can result in underestimated CT lifetime prevalence. Antibody testing might improve this estimate. We assessed CT antibody positivity and predictive factors thereof in the Netherlands Chlamydia Cohort Study. Women who had ≥1 CT Nucleic Acid Amplification Test (NAAT) in the study (2008–2011) and who provided self-reported information on NAATs were tested for CT major outer membrane protein specific IgG in serum (2016). CT antibody positivity was assessed and predictive factors were identified using multivariable logistic regressions, separately for CT-positive women (≥1 positive NAAT or ≥1 self-reported positive CT test) and CT-negative women (negative by study NAAT and self-report). Of the 3,613 women studied, 833 (23.1%) were CT -positive. Among the CT-negative women, 208 (7.5%, 95% CI 6.5–8.5) tested positive for CT antibodies. This increased CT lifetime prevalence with 5.8% (95% CI 5.0–6.5). Among women with a CT-positive history, 338 (40.6%, 95% CI 38.5–44.1) tested positive. Predictive factors for antibody positivity related to lower social economic status, sexual risk behavior, multiple infections, higher body mass index, and non-smoking. CT antibody testing significantly increased the lifetime prevalence. Combining NAAT outcomes, self-reported positive tests, and antibody testing reduced misclassification in CT prevalence estimates. MDPI 2019-10-11 /pmc/articles/PMC6843155/ /pubmed/31614620 http://dx.doi.org/10.3390/microorganisms7100442 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hoenderboom, Bernice M.
van Willige, Michelle E.
Land, Jolande A.
Pleijster, Jolein
Götz, Hannelore M.
van Bergen, Jan E. A. M.
Dukers-Muijrers, Nicole H. T. M.
Hoebe, Christian J. P. A.
van Benthem, Birgit H. B.
Morré, Servaas A.
Antibody Testing in Estimating Past Exposure to Chlamydia trachomatis in The Netherlands Chlamydia Cohort Study
title Antibody Testing in Estimating Past Exposure to Chlamydia trachomatis in The Netherlands Chlamydia Cohort Study
title_full Antibody Testing in Estimating Past Exposure to Chlamydia trachomatis in The Netherlands Chlamydia Cohort Study
title_fullStr Antibody Testing in Estimating Past Exposure to Chlamydia trachomatis in The Netherlands Chlamydia Cohort Study
title_full_unstemmed Antibody Testing in Estimating Past Exposure to Chlamydia trachomatis in The Netherlands Chlamydia Cohort Study
title_short Antibody Testing in Estimating Past Exposure to Chlamydia trachomatis in The Netherlands Chlamydia Cohort Study
title_sort antibody testing in estimating past exposure to chlamydia trachomatis in the netherlands chlamydia cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6843155/
https://www.ncbi.nlm.nih.gov/pubmed/31614620
http://dx.doi.org/10.3390/microorganisms7100442
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