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Age-Period-Cohort Analysis on the Time Trend of Hepatitis B Incidence in Four Prefectures of Southern Xinjiang, China from 2005 to 2017

Objective: The influence of age, period, and cohort on Hepatitis B (HB) incidence in four prefectures of southern Xinjiang, China is still not clear. This paper aims to analyze the long-term trend of the HB incidence in four prefectures of southern Xinjiang, China and to estimate the independent imp...

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Detalles Bibliográficos
Autores principales: Ji, Weidong, Xie, Na, He, Daihai, Wang, Weiming, Li, Hui, Wang, Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6843167/
https://www.ncbi.nlm.nih.gov/pubmed/31615013
http://dx.doi.org/10.3390/ijerph16203886
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author Ji, Weidong
Xie, Na
He, Daihai
Wang, Weiming
Li, Hui
Wang, Kai
author_facet Ji, Weidong
Xie, Na
He, Daihai
Wang, Weiming
Li, Hui
Wang, Kai
author_sort Ji, Weidong
collection PubMed
description Objective: The influence of age, period, and cohort on Hepatitis B (HB) incidence in four prefectures of southern Xinjiang, China is still not clear. This paper aims to analyze the long-term trend of the HB incidence in four prefectures of southern Xinjiang, China and to estimate the independent impact of age, period and cohort, as well as to predict the development trend of HB incidence in male and female groups, then to identify the targeted population for HB screening by the model fitting and prediction. Method: The data were from the Case List of HB Cases Reported in the Infectious Disease Reporting Information Management System and the Xinjiang Statistical Yearbook of China. The age-period-cohort (APC) model was used to estimate the impacts of age, period and cohort on HB incidence, which could be used to predict the HB incidence in specific age groups of men and women. Results: Under the influence of age effect, the incidence of HB in males had two peaks (20–35 years old and 60–80 years old), the influence of age effect on the incidence of HB in females was lower than that of males and the obvious peak was between 20–30 years old; the period effect on the HB incidence in males and females fluctuated greatly and the fluctuation degree of influence on males was bigger than that of women. The HB incidence among males and females in the four regions tended to be affected by cohort effect, which reached a peak after 1990 and then declined sharply and gradually became stabilized. By predicting the HB incidence from 2018 to 2022, we found that there were significant differences in HB incidence among people over 35 years old, under 35 years old and the whole population in four prefectures of southern Xinjiang, China. Conclusions: Although the incidence of HB in some regions shows a downward trend, there is still an obvious upward trend of incidences in other places. In our paper, results indicate that the burden of HB incidence may be extended in the future, so we hope this can draw the attention of relative departments. These results reveal the differences of incidence between males and females as well, so respective measures of the two groups’ functions are essential.
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spelling pubmed-68431672019-11-25 Age-Period-Cohort Analysis on the Time Trend of Hepatitis B Incidence in Four Prefectures of Southern Xinjiang, China from 2005 to 2017 Ji, Weidong Xie, Na He, Daihai Wang, Weiming Li, Hui Wang, Kai Int J Environ Res Public Health Article Objective: The influence of age, period, and cohort on Hepatitis B (HB) incidence in four prefectures of southern Xinjiang, China is still not clear. This paper aims to analyze the long-term trend of the HB incidence in four prefectures of southern Xinjiang, China and to estimate the independent impact of age, period and cohort, as well as to predict the development trend of HB incidence in male and female groups, then to identify the targeted population for HB screening by the model fitting and prediction. Method: The data were from the Case List of HB Cases Reported in the Infectious Disease Reporting Information Management System and the Xinjiang Statistical Yearbook of China. The age-period-cohort (APC) model was used to estimate the impacts of age, period and cohort on HB incidence, which could be used to predict the HB incidence in specific age groups of men and women. Results: Under the influence of age effect, the incidence of HB in males had two peaks (20–35 years old and 60–80 years old), the influence of age effect on the incidence of HB in females was lower than that of males and the obvious peak was between 20–30 years old; the period effect on the HB incidence in males and females fluctuated greatly and the fluctuation degree of influence on males was bigger than that of women. The HB incidence among males and females in the four regions tended to be affected by cohort effect, which reached a peak after 1990 and then declined sharply and gradually became stabilized. By predicting the HB incidence from 2018 to 2022, we found that there were significant differences in HB incidence among people over 35 years old, under 35 years old and the whole population in four prefectures of southern Xinjiang, China. Conclusions: Although the incidence of HB in some regions shows a downward trend, there is still an obvious upward trend of incidences in other places. In our paper, results indicate that the burden of HB incidence may be extended in the future, so we hope this can draw the attention of relative departments. These results reveal the differences of incidence between males and females as well, so respective measures of the two groups’ functions are essential. MDPI 2019-10-14 2019-10 /pmc/articles/PMC6843167/ /pubmed/31615013 http://dx.doi.org/10.3390/ijerph16203886 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ji, Weidong
Xie, Na
He, Daihai
Wang, Weiming
Li, Hui
Wang, Kai
Age-Period-Cohort Analysis on the Time Trend of Hepatitis B Incidence in Four Prefectures of Southern Xinjiang, China from 2005 to 2017
title Age-Period-Cohort Analysis on the Time Trend of Hepatitis B Incidence in Four Prefectures of Southern Xinjiang, China from 2005 to 2017
title_full Age-Period-Cohort Analysis on the Time Trend of Hepatitis B Incidence in Four Prefectures of Southern Xinjiang, China from 2005 to 2017
title_fullStr Age-Period-Cohort Analysis on the Time Trend of Hepatitis B Incidence in Four Prefectures of Southern Xinjiang, China from 2005 to 2017
title_full_unstemmed Age-Period-Cohort Analysis on the Time Trend of Hepatitis B Incidence in Four Prefectures of Southern Xinjiang, China from 2005 to 2017
title_short Age-Period-Cohort Analysis on the Time Trend of Hepatitis B Incidence in Four Prefectures of Southern Xinjiang, China from 2005 to 2017
title_sort age-period-cohort analysis on the time trend of hepatitis b incidence in four prefectures of southern xinjiang, china from 2005 to 2017
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6843167/
https://www.ncbi.nlm.nih.gov/pubmed/31615013
http://dx.doi.org/10.3390/ijerph16203886
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