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Skin Melanoma and Subsequent Risk of Prostate Cancer: A Lithuanian Cancer Registry Study

Emerging data indicates that melanoma may be linked to prostate cancer. We evaluated if the incidence of melanoma was associated with subsequent risk of prostate cancer (PC). We extracted data from the Lithuanian cancer registry from 1993 to 2012. We calculated the standardized incidence ratios (SIR...

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Autores principales: Patasius, Ausvydas, Urbonas, Vincas, Smailyte, Giedre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6843351/
https://www.ncbi.nlm.nih.gov/pubmed/31618913
http://dx.doi.org/10.3390/ijerph16203915
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author Patasius, Ausvydas
Urbonas, Vincas
Smailyte, Giedre
author_facet Patasius, Ausvydas
Urbonas, Vincas
Smailyte, Giedre
author_sort Patasius, Ausvydas
collection PubMed
description Emerging data indicates that melanoma may be linked to prostate cancer. We evaluated if the incidence of melanoma was associated with subsequent risk of prostate cancer (PC). We extracted data from the Lithuanian cancer registry from 1993 to 2012. We calculated the standardized incidence ratios (SIRs) for PC as a ratio of observed number of cancer cases in people with previous melanoma diagnosis to the expected number of cancer cases in the underlying general population. Therein, 95% confidence intervals for the SIRs were estimated assuming the number of observed cancer cases follows the Poisson distribution. Overall, 65 PCs were observed versus 52.5 expected (SIR 1.24; 95% CI: 0.97–1.58) within a period of 24 years. A significantly increased risk of PC was found in patients with melanoma diagnosis over 70 years (SIR 1.62; 95% CI: 1.11–2.39) and in two periods of diagnosis (SIRs 1.76 and 1.62 in 1993–1997 and 2009–2012, respectively). A significantly increased risk was also found five to nine years after melanoma diagnosis (SIR 1.58; 95% CI: 1.05–2.38). Further studies are needed to evaluate the relationship between melanoma and subsequent risk of prostate cancer.
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spelling pubmed-68433512019-11-25 Skin Melanoma and Subsequent Risk of Prostate Cancer: A Lithuanian Cancer Registry Study Patasius, Ausvydas Urbonas, Vincas Smailyte, Giedre Int J Environ Res Public Health Brief Report Emerging data indicates that melanoma may be linked to prostate cancer. We evaluated if the incidence of melanoma was associated with subsequent risk of prostate cancer (PC). We extracted data from the Lithuanian cancer registry from 1993 to 2012. We calculated the standardized incidence ratios (SIRs) for PC as a ratio of observed number of cancer cases in people with previous melanoma diagnosis to the expected number of cancer cases in the underlying general population. Therein, 95% confidence intervals for the SIRs were estimated assuming the number of observed cancer cases follows the Poisson distribution. Overall, 65 PCs were observed versus 52.5 expected (SIR 1.24; 95% CI: 0.97–1.58) within a period of 24 years. A significantly increased risk of PC was found in patients with melanoma diagnosis over 70 years (SIR 1.62; 95% CI: 1.11–2.39) and in two periods of diagnosis (SIRs 1.76 and 1.62 in 1993–1997 and 2009–2012, respectively). A significantly increased risk was also found five to nine years after melanoma diagnosis (SIR 1.58; 95% CI: 1.05–2.38). Further studies are needed to evaluate the relationship between melanoma and subsequent risk of prostate cancer. MDPI 2019-10-15 2019-10 /pmc/articles/PMC6843351/ /pubmed/31618913 http://dx.doi.org/10.3390/ijerph16203915 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Patasius, Ausvydas
Urbonas, Vincas
Smailyte, Giedre
Skin Melanoma and Subsequent Risk of Prostate Cancer: A Lithuanian Cancer Registry Study
title Skin Melanoma and Subsequent Risk of Prostate Cancer: A Lithuanian Cancer Registry Study
title_full Skin Melanoma and Subsequent Risk of Prostate Cancer: A Lithuanian Cancer Registry Study
title_fullStr Skin Melanoma and Subsequent Risk of Prostate Cancer: A Lithuanian Cancer Registry Study
title_full_unstemmed Skin Melanoma and Subsequent Risk of Prostate Cancer: A Lithuanian Cancer Registry Study
title_short Skin Melanoma and Subsequent Risk of Prostate Cancer: A Lithuanian Cancer Registry Study
title_sort skin melanoma and subsequent risk of prostate cancer: a lithuanian cancer registry study
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6843351/
https://www.ncbi.nlm.nih.gov/pubmed/31618913
http://dx.doi.org/10.3390/ijerph16203915
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